CLCA1 Antibodies

AND CLCA1 ELISA kits, CLCA1 Proteins

Many biological assays use antibodies to detect CLCA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCA1 antibodies...

We validate the specificity of these antibodies to CLCA1 by testing them on tissues known to express CLCA1 positively and negatively. Browse below to find the CLCA1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLCA1 Infographic by Boster Bio

All CLCA1 Products

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Specificity

Applications

Price

Anti-CLCA1 Antibody

Mouse, Rat

IF, IHC, WB

$405
Cat # A03318
100ul

Anti-CLCA1 Mouse Monoclonal Antibody [Clone ID: OTI8E7]

Human

IHC, WB

$523
Cat # M03318
100 µl

CLCA1 Overview

Facts about Calcium-activated chloride channel regulator 1.

CLCA1 3D structure. Source: alphafold

Calcium-activated chloride channel regulator 1 (CLCA1)

May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR.

May be involved in the regulation of mucus secretion or production by goblet cells. Involved in the regulation of tissue inflammation in the innate immune reaction.

Gene Information

Human
Gene Name:	CLCA1
Uniprot:	A8K7I4
Entrez:	1179

Family

Belongs to:

CLCR family

Alternative Names

CaCC; CaCC-1; Calcium-activated chloride channel family member 1; Calcium-activated chloride channel protein 1; chloride channel accessory 1; chloride channel regulator 1; chloride channel regulator; chloride channel, calcium activated, family member 1; CLCA1; CLCRG1; FLJ95147; GOB5; hCaCC-1; HCLCA1

Molecular Weight

Mass (kDA):
100.226 kDA

Genomic Context


Human

Location:	1p22.3
Sequence:	1; NC_000001.11 (86468927..86500259)

Tissue Specificity

Highly expressed in small intestine and colon namely in intestinal basal crypt epithelia and goblet cells, and appendix. Weakly expressed in uterus, testis and kidney. Expressed in the airways epithelium of both asthmatic and healthy patients. Expressed in the bronchial epithelium, especially in mucus- producing goblet cells. Expressed in normal turbinate mucosa and nasal polyp. Expressed in.

Subcellular Localizations

Secreted, extracellular space. Cell membrane; Peripheral membrane protein; Extracellular side. Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.

Diseases

Cystic Fibrosis
Asthma
Fibrosis
Inflammation
Chronic Obstructive Airway Disease
Lung Diseases
Lung Diseases, Obstructive
Neoplasms
Hyperplasia
Metaplasia
Tissue Adhesions
Airway Obstruction
Mucinous Adenocarcinoma

Airway Disease
Malignant Neoplasms
Allergic Asthma
Sinusitis
Allergy
Horse Diseases
Neoplasm Metastasis

Pathways

Secretion
Transport
Pathogenesis
Ion Transport
Cell Adhesion
Immune Response
Mucus Secretion
Sensitization
Cell Cycle
Cell Proliferation
Anion Transport
Chloride Transport
Fluid Transport

Cell Activation
Cell Migration
Fertilization
Muscle Contraction
Protein Secretion
Reverse Transcription
System Development

PTMs

Phosphorylation

Cleavage

Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCA1

References

PMID: 9828122 by Gruber A.D., et al. Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins.

PMID: 10437792 by Agnel M., et al. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.