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CLCN1 Antibodies

AND CLCN1 ELISA kits, CLCN1 Proteins

Many biological assays use antibodies to detect CLCN1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCN1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCN1 antibodies...

We validate the specificity of these antibodies to CLCN1 by testing them on tissues known to express CLCN1 positively and negatively. Browse below to find the CLCN1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CLCN1 Infographic by Boster Bio

CLCN1 protein infographic

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Anti-Chloride channel protein 1 CLCN1 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A01904
100ul

CLCN1 Overview

Facts about Chloride channel protein 1.

CLCN1 3D structure

CLCN1 3D structure. Source: alphafold

Chloride channel protein 1 (CLCN1)

Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an essential role in membrane repolarization in skeletal muscle cells after muscle contraction.

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Gene Information

Human
Gene Name:	CLCN1
Uniprot:	P35523
Entrez:	1180

Gene Information

Family

Belongs to:

chloride channel (TC 2.A.49) family

Family

Alternative Names

chloride channel 1, skeletal muscle; Chloride channel protein, skeletal muscle; clC-1; CLC1chloride channel protein 1; MGC138361; MGC142055

Molecular Weight

Mass (kDA):
108.626 kDA

Molecular Weight

Genomic Context


Human

Location:	7q34
Sequence:	7; NC_000007.14 (143316111..143352083)

Tissue Specificity

Predominantly expressed in skeletal muscles.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Subcellular Localization

Diseases

Myotonia Congenita
Myopathy
Weakness
Dystrophy
Myotonic Dystrophy
Generalized Myotonia Of Thomsen
Hypertrophy
Myotonic Disorders
Muscle Weakness
Muscular Stiffness
Dystrophia Myotonica 2
Channelopathies

Muscular Dystrophy
Hereditary Diseases
Periodic Paralysis (finding)
Pain
Paramyotonia Congenita (disorder)
Myalgia
Neuromuscular Diseases

Disease

Interacting Proteins

APPBP2
FAM9B

Interacting Proteins

Pathways

Muscle Hypertrophy
Pathogenesis
Muscle Contraction
Rna Splicing
Rna Processing
Relaxation Of Muscle
Relaxation Of Skeletal Muscle
Regulation Of Growth
Membrane Hyperpolarization
Regulation Of Intracellular Ph
Muscle Atrophy
Localization

Chondrocyte Differentiation
Chondrocyte Proliferation
Myotube Differentiation
Mrna Splicing
Membrane Depolarization
Membrane Repolarization
Cell Volume Homeostasis

Pathways

PTMs

Phosphoprotein

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCN1

References

PMID: 8112288 by Steinmeyer K., et al. Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).

PMID: 1379744 by Koch M.C., et al. The skeletal muscle chloride channel in dominant and recessive human myotonia.