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, No Gclids
CLASP2 Antibodies
AND CLASP2 ELISA kits, CLASP2 Proteins
Many biological assays use antibodies to detect CLASP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLASP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLASP2 antibodies...
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CLASP2 Infographic by Boster Bio
All CLASP2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03579-1
100 μg/vial
Cat # A03579-1
100 μg/vial
CLASP2 Overview
Facts about CLIP-associating protein 2.
CLIP-associating protein 2 (CLASP2)
Microtubule plus-end tracking protein which promotes the stabilization of dynamic microtubules (PubMed:26003921). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell.
May act in the cell cortex to boost the frequency of saving of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLASP2 |
| Uniprot: | O75122 |
| Entrez: | 23122 |
Family
| Belongs to: |
|---|
| CLASP family |
Alternative Names
CLIP-associating protein 2; cytoplasmic linker associated protein 2; Cytoplasmic linker-associated protein 2; hOrbit2; KIAA0627; multiple asters (Mast)-like homolog 2; Protein Orbit homolog 2
Molecular Weight
Mass (kDA):
141.064 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p22.3 |
| Sequence: | 3; NC_000003.12 (33496245..33718356, complement) |
Tissue Specificity
Brain-specific.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane. Localizes to microtubule plus ends (PubMed:15631994). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase (PubMed:16866869, PubMed:16914514). In migrating cells localizes to the plus ends of microtubules with
Diseases
- Tissue Adhesions
- Aneuploidy
- Adenomatous Polyposis Coli
- Malignant Neoplasms
- Polyposis
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Anemia
- Muscular Fasciculation
- Neurodegenerative Disorders
- Antibiotic-associated Diarrhea
- Protrusion
Interacting Proteins
- Clip2
- MAPRE1
Pathways
- Mitosis
- Transport
- Localization
- Cell Migration
- Chromosome Segregation
- Interphase
- Anaphase
- Cell Motility
- Cell Division
- Golgi Organization
- Spindle Assembly
- Metaphase
- Rna Interference
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLASP2
bosterbio.com/bosterbio-gene-info-cards/CLASP2
References
PMID: 11290329 by Akhmanova A., et al. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
PMID: 15207236 by Lee H., et al. The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.