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- Table of Contents
Facts about Creatine kinase B-type.
creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Human | |
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Gene Name: | CKB |
Uniprot: | P12277 |
Entrez: | 1152 |
Belongs to: |
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ATP:guanido phosphotransferase family |
B-CK; CKB; Creatine Kinase BB
Mass (kDA):
42.644 kDA
Human | |
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Location: | 14q32.33 |
Sequence: | 14; NC_000014.9 (103519667..103522833, complement) |
Cytoplasm.
If you're looking for an anti-CKB antibody that can react with human, mouse and rats' cells, then you've found the right spot. This article will focus on the Boster Bio anti-Creatine kinase antibody (CKB) that has been examined in flow cytometry as well as IF. It is a monoclonal and highly specific antibody that reacts with human, mouse and rat cell.
The company, which produces anti-Creatine-Kinasase-B type/CKB is a leader in immunological reagents. Established in 1993 by renowned histologist Steven Xia, the company's portfolio includes picogram-sensitive ELISA kits IHC-ready antibodies, as well as a broader range of high-sensitivity ELISA products. Those products have earned the confidence of researchers worldwide and are guaranteed by the Boster Quality Guarantee.
Boster Bio's anti-Creatine Knase B/CKB antibody has been validated flow Cytometry, IF and WB as well as in human tissue, cells, and other biological samples. It reacts with Creatine Kinase B in human and mouse cells.
Creatine Kinase B is an enzyme found in humans that supplies energy via phosphate hydrolysis. This is necessary for the normal functioning of many cellular systems. The human cytoplasmic Creatine kinase B (CK-B) is a 381-amino acid protein that binds to phosphorus within our bodies. It is a member of the ATP Guanido phosphotransferase family.
For a complete description of the recombinant CKB antibody, visit the Sanbio website. In this test it was not able to connect with the corresponding product rMBP. Alternatively, it could interact with NNVCP but not with rCKB. CKB can bind to NNVCP in the laboratory and boost NNVCP production in the GF-1 cells.
To determine the specificity of anti-Ckba antibodies, the protein was subjected to a far-Western blot analysis. The target proteins were isolated by an Escherichia-coli expression system and compared to rMBP, which was a negative control. Anti-Ckba antibodies were not able to recognize rMBP as the target protein, whereas anti-rNNVCP did. The binding protein was incubated for two hours at ambient temperature.
CKB is an important enzyme in the production and maintenance of ATP in the body. It also regulates the production of ATP within the host cell. This is helpful in NNV replication. Antibodies against CKB are therefore crucial for viral research. They are available in a variety of formats to allow for the detection and analysis of CKB. Although there aren't any reported adverse reactions from Boster Bio anti Creatine kinase B/CKB antibody there are some that could be.
The CKB Marker is an biomarker with a variety of applications in the field of oncology. The marker may increase the confidence of doctors. It is packed with extensive information about cancer-related genomic information. This includes thousands of descriptions of gene variants and therapies and evidence of their effectiveness. Additionally, JAX-CKB can provide clinicians with a wealth of literature citations, FDA drug labels, and clinical trials to support the results of a genomic profile.
The CKB marker is a gene expressed in different types of cancer cells and is the reason for metastatic potential. It is secreted by the cells and creates phosphocreatine. This phosphocreatine is reimported into cancer cells and helps to promote CK dependent survival and liver colonization. The Yes-associated protein mechanosensitively targets CKB gene. It increases its expression in response to stiff substrates and it aids in the invasion of cells collectively and the process of chemotaxis. CKB is located in the stroma. It is able to migrate into migrating cells and supplies them with ATP. Reorganization of Actin requires ATP.
PMID: 3034271 by Villarreal-Levy G., et al. Human creatine kinase: isolation and sequence analysis of cDNA clones for the B subunit, development of subunit specific probes and determination of gene copy number.
PMID: 3692484 by Mariman E.C.M., et al. Structure and expression of the human creatine kinase B gene.