This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
CIRBP Antibodies
AND CIRBP ELISA kits, CIRBP Proteins
Many biological assays use antibodies to detect CIRBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CIRBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CIRBP antibodies...
Previous: CDH12
Next: TBCB
CIRBP Infographic by Boster Bio
All CIRBP Products
Product
Figures
Specificity
Applications
Price
Anti-CIRBP Rabbit Monoclonal Antibody
1 Citations
Human
IP, IF, IHC, ICC, WB
$370
Cat # M04103
100 μl/vial
Cat # M04103
100 μl/vial
CIRBP Overview
Facts about Cold-inducible RNA-binding protein.
Cold-inducible RNA-binding protein (CIRBP)
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator.
Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.
Gene Information
| Human | |
|---|---|
| Gene Name: | CIRBP |
| Uniprot: | Q14011 |
| Entrez: | 1153 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
A18 hnRNP; A18HNRNP; CIRPcold-inducible RNA-binding protein; cold inducible RNA binding protein; cold inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP
Molecular Weight
Mass (kDA):
18.648 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (1269268..1274880) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus, nucleoplasm. Cytoplasm. Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
Diseases
- Malignant Neoplasms
- Hypoxia
- Brain Injuries
- Infertility
- Neoplasms
- Growth Arrest
- Growth Retardation
- Brain Ischemia
- Carcinoma
- Ischemia
- Physiological Stress
- Male Infertility
Interacting Proteins
- HNRNPK
- KHDRBS2
- LNX1
- RBMX
- RBMY1A1
- RBMY1F
- SNRPA
Pathways
- Cell Growth
- Translation
- Spermatogenesis
- Cell Cycle
- Cell Proliferation
- Immune Response
- G1 Phase
- Localization
- Senescence
- Methylation
- Transport
- Response To Lipopolysaccharide
- Interferon-gamma Production
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CIRBP
bosterbio.com/bosterbio-gene-info-cards/CIRBP
References
PMID: 9434172 by Nishiyama H., et al. Cloning and characterization of human CIRP (cold-inducible RNA- binding protein) cDNA and chromosomal assignment of the gene.
PMID: 9334257 by Sheikh M.S., et al. Identification of several human homologs of hamster DNA damage- inducible transcripts. Cloning and characterization of a novel UV- inducible cDNA that codes for a putative RNA-binding protein.
1 Publications of Boster CIRBP Antibodies & ELISA Kits
- PubMed ID: 10.1093/icvts/ivx262, Cold-inducible ribonucleic acid-binding protein attenuates acute kidney injuries...
*More publications can be found for each product on its corresponding product page