CKAP5 Antibodies

Cytoskeleton-associated protein 5 (CKAP5)

Binds to the plus end of microtubules and modulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase.

Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.

Gene Information

Human
Gene Name:	CKAP5
Uniprot:	Q14008
Entrez:	9793

Family

Belongs to:
TOG/XMAP215 family

Alternative Names

CHTOG; Ch-TOG; Colonic and hepatic tumor over-expressed gene protein; cytoskeleton associated protein 5; cytoskeleton-associated protein 5; EC 2.7.7.6; EC 3.1.1.29; KIAA0097FLJ35359; MSPS; TOG; TOGp

Molecular Weight

Mass (kDA):
225.495 kDA

Genomic Context

Human
Location:	11p11.2
Sequence:	11; NC_000011.10 (46743048..46846308, complement)

Tissue Specificity

Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm

Diseases

• Neoplasms
• Malignant Neoplasms
• Sclerosis
• Multiple Myeloma
• Lung Neoplasms
• Non-small Cell Lung Carcinoma
• Liver Neoplasms
• Lymphangioleiomyomatosis

• Tuberous Sclerosis
• Malignant Neoplasm Of Lung

Interacting Proteins

• NCK1
• SLAIN2
• TACC1
• TACC3

Pathways

• Mitosis
• Translation
• Cell Cycle
• Localization
• Cell Division
• Transport
• Abscission
• Rna Splicing
• Cell Growth

• Mrna Polyadenylation
• Microtubule Polymerization
• Rna Interference
• Spindle Assembly

PTMs

• Acetylation

• Phosphoprotein

Research Areas

• Cancer
• Cell Biology
• Cell Cycle and Replication
• Cellular Markers
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CKAP5

Boster Bio - Best Uses Of The CKAP5 Marker

This article discusses Boster's high-affinity primary antibodies against CKAP5 and its various uses. The company is a world-renowned manufacturer of biomedical antibodies and its research is highly regarded. Read on to learn more about the company's history, its product lines and its current projects. Read on to discover what makes Boster unique. Here are the best uses of Boster primary antibodies against CKAP5:

Boster offers high-affinity primary antibodies for CKAP5

If you're looking for an antibody that can detect CKAP5, Boster Bio has you covered. This product is available as a monoclonal or polyclonal antibody and has been extensively validated by Boster's scientists on multiple platforms. They have tested the antibody on known positive and negative samples to ensure its specificity and high affinity. The antibody comes in 100ul Liquid form.

Boster's history

The history of the name Boster began when Steven Boster developed his first product in 1993, earning himself the nickname "he who converts science in the lavatory." The company grew to become one of China's largest catalog antibody companies in the late 90s. During this period, Steven Boster also developed a proprietary ELISA platform, PicoKine(tm). These ELISA kits use proprietary trade secrets to deliver highly sensitive reagents that allow researchers to analyze biological samples with the highest sensitivity.

Boster's history is structured so that the reader can understand the significance of disabled individuals within the plantation society of the time. While the book covers various aspects of slavery in the American South, it is especially interesting to note how disabled fugitives were exhibited as an alternative to slaves. Boster ties the story of disabled fugitives to the history of slavery by relating how abolitionists exhibited the slaves to prospective buyers.

Current projects

The CKAP5 gene, which is a highly expressed evolutionarily conserved member of the XMAP215 family of microtubule-associated proteins, is upregulated in hepatic and colonic cancers. CKAP5 expression correlates with survival of patients with head and neck cancer, and high CKAP5 expression is associated with better outcomes in this type of cancer. Currently, there are several active projects based on this gene.

Contact information

The CKAP5 gene encodes a microtubule-associated protein. It is a homolog of XMAP215 from Xenopus. Contact information for the CKAP5 marker can be found on the UCSC genome browser. In a previous study, the marker was localized on the surface of human fibroblasts. To find out more about this marker, visit the UCSC genome browser.