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CKAP5 Antibodies
AND CKAP5 ELISA kits, CKAP5 Proteins
Many biological assays use antibodies to detect CKAP5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CKAP5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CKAP5 antibodies...
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CKAP5 Infographic by Boster Bio
All CKAP5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05324
100 μg/vial
Cat # A05324
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05324
100 μg/vial
Cat # M05324
100 μg/vial
CKAP5 Overview
Facts about Cytoskeleton-associated protein 5.
Cytoskeleton-associated protein 5 (CKAP5)
Binds to the plus end of microtubules and modulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase.
Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.
Gene Information
| Human | |
|---|---|
| Gene Name: | CKAP5 |
| Uniprot: | Q14008 |
| Entrez: | 9793 |
Family
| Belongs to: |
|---|
| TOG/XMAP215 family |
Alternative Names
CHTOG; Ch-TOG; Colonic and hepatic tumor over-expressed gene protein; cytoskeleton associated protein 5; cytoskeleton-associated protein 5; EC 2.7.7.6; EC 3.1.1.29; KIAA0097FLJ35359; MSPS; TOG; TOGp
Molecular Weight
Mass (kDA):
225.495 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p11.2 |
| Sequence: | 11; NC_000011.10 (46743048..46846308, complement) |
Tissue Specificity
Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas. Expression is elevated in the brain; highly expressed in the Purkinje cell bodies of the cerebellum.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Detected on centrosomes and kinetochores during interphase and mitosis independently from TACC3 and clathrin. Located to spindle poles and microtubules during mitosis. In complex with TACC3 localized to microtubule plus-ends in mitosis and interphase. In complex with TACC3 and clathrin localized to inter-microtubule bridges in mitotic spindles. Accumulation sites at microtubule plus ends protruded approximately 100 nm
Diseases
- Neoplasms
- Malignant Neoplasms
- Sclerosis
- Multiple Myeloma
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Liver Neoplasms
- Lymphangioleiomyomatosis
Interacting Proteins
- NCK1
- SLAIN2
- TACC1
- TACC3
Pathways
- Mitosis
- Translation
- Cell Cycle
- Localization
- Cell Division
- Transport
- Abscission
- Rna Splicing
- Cell Growth
PTMs
- Acetylation
Research Areas
- Cancer
- Cell Biology
- Cell Cycle and Replication
- Cellular Markers
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CKAP5
bosterbio.com/bosterbio-gene-info-cards/CKAP5
References
PMID: 8536682 by Charrasse S., et al. Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors.
PMID: 8832653 by Charrasse S., et al. Expression of the tumor over-expressed ch-TOG gene in human and baboon brain.