CHSY1 Antibodies

AND CHSY1 ELISA kits, CHSY1 Proteins

Many biological assays use antibodies to detect CHSY1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHSY1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHSY1 antibodies...

We validate the specificity of these antibodies to CHSY1 by testing them on tissues known to express CHSY1 positively and negatively. Browse below to find the CHSY1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHSY1 Infographic by Boster Bio

All CHSY1 Products

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Anti-Chondroitin sulfate synthase 1 CHSY1 Antibody

Human

IHC, WB

$360
Cat # A07580
100 µl

Anti-Chondroitin sulfate synthase 1 CHSY1 Antibody

4 Q&As

Human, Mouse

$399
Cat # A07580-1
100μl

Anti-Chondroitin sulfate synthase 1 CHSY1 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A07580-2
100ul

CHSY1 Overview

Facts about Chondroitin sulfate synthase 1.

CHSY1 3D structure. Source: alphafold

Chondroitin sulfate synthase 1 (CHSY1)

Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer.

Involved in the negative charge of osteogenesis likely through the modulation of NOTCH signaling. .

Gene Information

Human
Gene Name:	CHSY1
Uniprot:	Q86X52
Entrez:	22856

Family

Belongs to:

chondroitin N-acetylgalactosaminyltransferase family

Alternative Names

Chondroitin glucuronyltransferase 1; chondroitin glucuronyltransferase II; chondroitin sulfate synthase 1; Chondroitin synthase 1; CHSY; ChSy-1; CSS1DKFZp434M032; EC 2.4.1.175; EC 2.4.1.226; FLJ58581; Glucuronosyl-N-acetylgalactosaminyl-proteoglycan4-beta-N-acetylgalactosaminyltransferase 1; KIAA0990carbohydrate (chondroitin) synthase 1; N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 1; N-acetylgalactosaminyltransferase 1; N-acetylgalactosaminyltransferase II

Molecular Weight

Mass (kDA):
91.784 kDA

Genomic Context


Human

Location:	15q26.3
Sequence:	15; NC_000015.10 (101175727..101252048, complement)

Tissue Specificity

Ubiquitous, with the highest levels in placenta. Detected at low levels in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, adrenal gland, mammary gland, stomach, small intestine, lung and peripheral blood leukocytes.

Subcellular Localizations

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted.

Diseases

Brachydactyly
Neoplasms
Congenital Hand Deformities
Congenital Foot Deformity
Dermatomyositis
Glaucoma, Open-angle
Congenital Heart Defects
Multiple Myeloma
Lupus Erythematosus, Cutaneous
Headache
Dwarfism

Lupus Erythematosus, Systemic
Lupus Erythematosus, Discoid
Barrett Esophagus
Bone Diseases
Primary Open Angle Glaucoma
Complete Hearing Loss

Pathways

Rna Interference
Sulfation
Cell Proliferation
Cell Cycle
Bone Development
Metaphase

Wound Healing

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHSY1

References

PMID: 11514575 by Kitagawa H., et al. Molecular cloning and expression of a human chondroitin synthase.

PMID: 12716890 by Kitagawa H., et al. Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization.