CHRNE Antibodies

AND CHRNE ELISA kits, CHRNE Proteins

Many biological assays use antibodies to detect CHRNE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNE antibodies...

We validate the specificity of these antibodies to CHRNE by testing them on tissues known to express CHRNE positively and negatively. Browse below to find the CHRNE antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRNE Infographic by Boster Bio

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CHRNE Overview

Facts about Acetylcholine receptor subunit epsilon.

CHRNE 3D structure. Source: alphafold

Acetylcholine receptor subunit epsilon (CHRNE)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Gene Information

Human
Gene Name:	CHRNE
Uniprot:	Q04844
Entrez:	1145

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

acetylcholine receptor subunit epsilon; AchR epsilon subunit; ACHRE; ACHREFCCMS; cholinergic receptor, nicotinic, epsilon polypeptide; cholinergic receptor, nicotinic, epsilon; CHRNE; CMS1D; CMS1E; CMS2A; nAChR epsilon; Nicotinic Acetylcholine R epsilon; SCCMS

Molecular Weight

Mass (kDA):
54.697 kDA

Genomic Context


Human

Location:	17p13.2
Sequence:	17; NC_000017.11 (4897771..4905019, complement)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Myasthenic Syndromes, Congenital
Myasthenias
Weakness
Blepharoptosis
Myasthenia Gravis
Genetic Diseases, Inborn
Myopathy
Ophthalmoplegia
Infective Disorder
Muscle Hypotonia
Autoimmune Reaction

Cattle Diseases
Mutation, Out-of-frame
Asthenia
Atresia
Epidermolysis Bullosa
Thymus Neoplasms

Pathways

Pathogenesis
Localization
Synapse Maturation
Programmed Cell Death
Cell Cycle
Cell Death
Muscle Contraction
Metaphase

Histone Modification
Innervation
Rna Interference

PTMs

Phosphorylation
Cleavage

Acetylation
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNE

References

PMID: 7688301 by Beeson D.M.W., et al. Primary structure of the human muscle acetylcholine receptor. cDNA cloning of the gamma and epsilon subunits.

PMID: 15609996 by Ellison M., et al. Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes.