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CHRNA9 Antibodies
AND CHRNA9 ELISA kits, CHRNA9 Proteins
Many biological assays use antibodies to detect CHRNA9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNA9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNA9 antibodies...
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CHRNA9 Overview
Facts about Neuronal acetylcholine receptor subunit alpha-9.
Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9)
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that contributes to the opening of an ion-conducting channel across the plasma membrane (PubMed:11752216, PubMed:25282151).
The channel is permeable to a range of divalent cations such as calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, this can result in a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing.
Gene Information
| Human | |
|---|---|
| Gene Name: | CHRNA9 |
| Uniprot: | Q9UGM1 |
| Entrez: | 55584 |
Family
| Belongs to: |
|---|
| ligand-gated ion channel (TC 1.A.9) family |
Alternative Names
cholinergic receptor, nicotinic, alpha 9; cholinergic receptor, nicotinic, alpha polypeptide 9; CHRNA9; HSA243342; MGC142109; MGC142135; NACHR alpha 9; NACHR alpha-9; NACHRA9; NACHRA9acetylcholine receptor, neuronal nicotinic, alpha-9 subunit; neuronal acetylcholine receptor protein, alpha-9 subunit; neuronal acetylcholine receptor subunit alpha-9; Nicotinic Acetylcholine R alpha 9; Nicotinic Acetylcholine Ra 9; nicotinic acetylcholine receptor subunit alpha 9; Nicotinic acetylcholine receptor subunit alpha-9
Molecular Weight
Mass (kDA):
54.807 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p14 |
| Sequence: | 4; NC_000004.12 (40335333..40355217) |
Tissue Specificity
Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells.
Subcellular Localizations
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Diseases
- Pain
- Malignant Neoplasms
- Neuralgia
- Autoimmune Reaction
- Nicotine Dependence
- Malignant Neoplasm Of Lung
- Hearing Problem
- Malignant Neoplasm Of Breast
- Neoplasms
- Chimera Disorder
- Acantholysis
Pathways
- Synaptic Transmission
- Innervation
- Translation
- Cell Proliferation
- Pathogenesis
- Cell Activation
- Fertilization
- Immune Response
- Hypersensitivity
- Mast Cell Activation
- Rna Splicing
- Cytokine Production
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNA9
bosterbio.com/bosterbio-gene-info-cards/CHRNA9
References
PMID: 11752216 by Sgard F., et al. A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit.
PMID: 12697997 by Lustig L.R., et al. Chromosome location and characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) gene.