CHRNA7 Antibodies

AND CHRNA7 ELISA kits, CHRNA7 Proteins

Many biological assays use antibodies to detect CHRNA7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNA7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNA7 antibodies...

We validate the specificity of these antibodies to CHRNA7 by testing them on tissues known to express CHRNA7 positively and negatively. Browse below to find the CHRNA7 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRNA7 Infographic by Boster Bio

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CHRNA7 Overview

Facts about Neuronal acetylcholine receptor subunit alpha-7.

CHRNA7 3D structure. Source: alphafold

Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Gene Information

Human
Gene Name:	CHRNA7
Uniprot:	P36544
Entrez:	1139

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

a7 nicotinic acetylcholine receptor; alpha 7 neuronal nicotinic acetylcholine receptor; alpha-7 nicotinic cholinergic receptor subunit; cholinergic receptor, nicotinic, alpha 7; cholinergic receptor, nicotinic, alpha polypeptide 7; CHRNA7; CHRNA7-2; NACHRA7; neuronal acetylcholine receptor protein, alpha-7 chain; neuronal acetylcholine receptor subunit alpha-7; Nicotinic Acetylcholine R alpha 7; Nicotinic Acetylcholine Ra 7

Molecular Weight

Mass (kDA):
56.449 kDA

Genomic Context


Human

Location:	15q13.3
Sequence:	15; NC_000015.10 (32030462..32173018)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Schizophrenia
Malnutrition
Epilepsy
Dysequilibrium Syndrome
Autistic Disorder
Psychotic Disorders
Bipolar Disorder
Impaired Cognition
Mental Disorders
Nicotine Dependence
Attention Deficit Hyperactivity Disorder
Tobacco Use Disorder

Developmental Delay (disorder)
Developmental Disabilities
Muscle Hypotonia
Alzheimer's Disease
Epilepsy, Generalized
Schizoaffective Disorder

Interacting Proteins

APP
CHRFAM7A
SLURP1

Pathways

Pathogenesis
Sensory Processing
Localization
Cognition
Translation
Dna Methylation
Methylation
Chromosome Localization
Synaptic Transmission
Cell Adhesion
Aging
Inflammatory Response

Swimming
System Development
Interphase
Central Nervous System Development
Posterior Neuropore Closure
Response To Stress
Sperm Motility

PTMs

Methylation

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNA7

References

PMID: 8145738 by Peng X., et al. Human alpha 7 acetylcholine receptor: cloning of the alpha 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha 7 homomers expressed in Xenopus oocytes.

PMID: 8906617 by Elliott K.J., et al. Comparative structure of human neuronal alpha 2-alpha 7 and beta 2- beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.