CHRNA4 Antibodies

AND CHRNA4 ELISA kits, CHRNA4 Proteins

Many biological assays use antibodies to detect CHRNA4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHRNA4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHRNA4 antibodies...

We validate the specificity of these antibodies to CHRNA4 by testing them on tissues known to express CHRNA4 positively and negatively. Browse below to find the CHRNA4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHRNA4 Infographic by Boster Bio

All CHRNA4 Products

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Product

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Specificity

Applications

Price

Nicotinic Acetylcholine Receptor alpha 4 (CHRNA4) (NM_000744) Human Recombinant Protein

$1062
Cat # PROTP43681
20 µg

Anti-CHRNA4 Antibody (N-Term)

Human, Mouse

$299
Cat # M02230
50 µl

Anti-ACHA4 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, WB

$370
Cat # M02230-1
100 μl/vial

CHRNA4 Overview

Facts about Neuronal acetylcholine receptor subunit alpha-4.

CHRNA4 3D structure. Source: alphafold

Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. .

Gene Information

Human
Gene Name:	CHRNA4
Uniprot:	P43681
Entrez:	1137

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

nAchRa4; BFNC; cholinergic receptor, nicotinic, alpha 4; cholinergic receptor, nicotinic, alpha polypeptide 4; CHRNA4; EBN; EBN1; ENFL1; FLJ95812; nAChR alpha 4; NACHR; NACHRA4; NACRA4; neuronal acetylcholine receptor subunit alpha-4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; Nicotinic Acetylcholine R alpha 4; Nicotinic Acetylcholine Ra4

Molecular Weight

Mass (kDA):
69.957 kDA

Genomic Context


Human

Location:	20q13.33
Sequence:	20; NC_000020.11 (63343223..63375471, complement)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.

Diseases

Epilepsy
Epilepsy, Frontal Lobe
Nicotine Dependence
Tobacco Use Disorder
Convulsions
Epilepsies, Partial
Attention Deficit Hyperactivity Disorder
Epilepsy, Generalized
Familial Benign Neonatal Epilepsy
Convulsion Neonatal
Febrile Convulsions
Dysequilibrium Syndrome

Malnutrition
Epilepsies, Myoclonic
Absence Epilepsy
Sleep Disorders
Schizophrenia
Idiopathic Generalized Epilepsy

Interacting Proteins

CHRNB2

Pathways

Cognition
Pathogenesis
Localization
Response To Nicotine
Chromosome Localization
Aging
Dna Repair
System Development
Nervous System Development
Cell Adhesion
Sensory Processing
Metaphase
Regulation Of Gene Expression

Neuroprotection
Regulation Of Nervous System Development
Drug Resistance
Cell Division
Reverse Transcription
Membrane Depolarization
Response To Methylphenidate

PTMs

Phosphorylation

Ribosylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHRNA4

References

PMID: 7721089 by Monteggia L.M., et al. Cloning and transient expression of genes encoding the human alpha-4 and beta-2 neuronal nicotinic acetylcholine receptor (nAChR) subunits.

PMID: 8833159 by Steinlein O.K., et al. Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4).