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- Table of Contents
Facts about Charged multivesicular body protein 5.
The MVB pathway appears to require the sequential use of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is discharged.
Human | |
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Gene Name: | CHMP5 |
Uniprot: | Q9NZZ3 |
Entrez: | 51510 |
Belongs to: |
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SNF7 family |
apoptosis-related protein PNAS-2; C9orf83; charged multivesicular body protein 5; chromatin modifying protein 5; Chromatin-modifying protein 5; chromosome 9 open reading frame 83; HSPC177; hVps60; PNAS-2; SNF7 domain containing 2; SNF7 domain-containing protein 2; SNF7DC2; Vacuolar protein sorting-associated protein 60; Vps60CGI-34
Mass (kDA):
24.571 kDA
Human | |
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Location: | 9p13.3 |
Sequence: | 9; NC_000009.12 (33264879..33282070) |
Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
PMID: 14519844 by Martin-Serrano J., et al. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.
PMID: 15644320 by Ward D.M., et al. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells.