CHD1 Antibodies

AND CHD1 ELISA kits, CHD1 Proteins

Many biological assays use antibodies to detect CHD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHD1 antibodies...

We validate the specificity of these antibodies to CHD1 by testing them on tissues known to express CHD1 positively and negatively. Browse below to find the CHD1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CHD1 Infographic by Boster Bio

All CHD1 Products

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Anti-CHD1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A01175-1
100 μg/vial

CHD1 Overview

Facts about Chromodomain-helicase-DNA-binding protein 1.

CHD1 3D structure. Source: alphafold

Chromodomain-helicase-DNA-binding protein 1 (CHD1)

ATP-dependent chromatin-remodeling factor which serves as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step.

Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a particular chromatin configuration across the genome.

Gene Information

Human
Gene Name:	CHD1
Uniprot:	O14646
Entrez:	1105

Family

Belongs to:

SNF2/RAD54 helicase family

Alternative Names

ATP-dependent helicase CHD1; CHD1; CHD-1; chromodomain helicase DNA binding protein 1; chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337; EC 3.6.1; EC 3.6.4.12

Molecular Weight

Mass (kDA):
196.688 kDA

Genomic Context


Human

Location:	5q15-q21.1
Sequence:	5; NC_000005.10 (98853985..98929772, complement)

Tissue Specificity

Expressed in many tissues including in the brain, where the highest level of expression is found in the cerebellum and basal ganglia.

Subcellular Localizations

Nucleus. Cytoplasm. Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.

Diseases

Malignant Neoplasms
Neoplasms
Stomach Neoplasms
Prostatic Neoplasms
Malignant Neoplasm Of Prostate
Malignant Neoplasm Of Stomach
Malignant Neoplasm Of Breast
Carcinoma
Mammary Neoplasms
Cell Transformation, Neoplastic
Hiv Infections
Leukemia

Neoplasm Metastasis
Charge Syndrome
Coronary Heart Disease
Non-neoplastic Disorder
Neuronal Migration Disorders
Ehlers-danlos Syndrome

Pathways

Chromatin Remodeling
Methylation
Atp-dependent Chromatin Remodeling
Chromatin Assembly
Histone Modification
Localization
Chromatin Organization
Dna Methylation
Histone Acetylation
Histone Methylation
Rna Interference
Nucleosome Positioning
Dna Replication

Nucleosome Assembly
Sex Determination
Interphase
Nucleosome Organization
Histone Exchange
Gene Silencing
Cell Growth

PTMs

Methylation
Phosphorylation
Acetylation
Deacetylation

Demethylation
Reduction
Cleavage
Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHD1

References

PMID: 9326634 by Woodage T., et al. Characterization of the CHD family of proteins.

PMID: 16263726 by Sims R.J. III, et al. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.