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CFLAR Antibodies
AND CFLAR ELISA kits, CFLAR Proteins
Many biological assays use antibodies to detect CFLAR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CFLAR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CFLAR antibodies...
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CFLAR Infographic by Boster Bio
All CFLAR Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC, WB
$370
Cat # A01295-1
100 μg/vial
Cat # A01295-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC-P, ICC, WB
$449
Cat # A01295-2
0.1 mg
Cat # A01295-2
0.1 mg
Human
IHC, WB
$523
Cat # M01295-1
100 µl
Cat # M01295-1
100 µl
CFLAR Overview
Facts about CASP8 and FADD-like apoptosis regulator.
CASP8 and FADD-like apoptosis regulator (CFLAR)
Apoptosis regulator protein which might function as a critical link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis.
A proteolytic fragment (p43) is probably retained in the death-inducing signaling complex (DISC) thereby blocking additional processing and recruiting of caspase-8 in the complex. Total length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | CFLAR |
| Uniprot: | O15519 |
| Entrez: | 8837 |
Family
| Belongs to: |
|---|
| peptidase C14A family |
Alternative Names
CASHFADD-like antiapoptotic molecule 1; CASP8 and FADD-like apoptosis regulator; CASP8AP1; Caspase homolog; Caspase-eight-related protein; Caspase-like apoptosis regulatory protein; caspase-related inducer of apoptosis; CASPER; CasperFLAME1; Cellular FLICE-like inhibitory protein; CFLAR; c-FLIPR; c-FLIPS; CLARPMACH-related inducer of toxicity; FADD-like apoptotic molecule; FLAME; FLAME-1; FLIP; I-FLICE; I-FLICEMRITc-FLIPFLIPc-FLIPL; Inhibitor of FLICE; usurpin beta; Usurpin
Molecular Weight
Mass (kDA):
55.344 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q33.1 |
| Sequence: | 2; NC_000002.12 (201116104..201176687) |
Tissue Specificity
Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Lymphoma
- Leukemia
- Malignant Paraganglionic Neoplasm
- Inflammation
- Autoimmune Reaction
- Cell Transformation, Neoplastic
- Prostatic Neoplasms
- Melanoma
- Adenocarcinoma
- Malignant Neoplasm Of Prostate
Interacting Proteins
- CASP10
- CASP8
- MAP2K1
- MAP2K7
- TRAF1
Pathways
- Cell Death
- Sensitization
- Pathogenesis
- Induction Of Apoptosis
- Cell Proliferation
- Programmed Cell Death
- Cell Cycle
- Cell Growth
- Rna Interference
- Immune Response
- Cell Activation
- Localization
- Translation
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Methylation
- Acetylation
- Dephosphorylation
Research Areas
- Apoptosis
- Cancer
- Cell Biology
- Signal Transduction
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CFLAR
bosterbio.com/bosterbio-gene-info-cards/CFLAR
References
PMID: 9208847 by Shu H.-B., et al. Casper is a FADD- and caspase-related inducer of apoptosis.
PMID: 9326610 by Han D.K.M., et al. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death.