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- Table of Contents
Facts about Ceramide kinase-like protein.
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Human | |
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Gene Name: | CERKL |
Uniprot: | Q49MI3 |
Entrez: | 375298 |
Belongs to: |
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No superfamily |
ceramide kinase-like protein; ceramide kinase-like; retinitis pigmentosa 26 (autosomal recessive); RP26
Mass (kDA):
62.622 kDA
Human | |
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Location: | 2q31.3 |
Sequence: | 2; NC_000002.12 (181536672..181657107, complement) |
Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver.
Cytoplasm. Nucleus, nucleolus. Enriched in nucleoli. May shuttle between nucleus and cytoplasm. Isoform 5 is not enriched in the nucleoli.; [Isoform 2]: Cytoplasm. Nucleus, nucleolus. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum.
PMID: 14681825 by Tuson M., et al. Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26).
PMID: 15708351 by Bornancin F., et al. Characterization of a ceramide kinase-like protein.