CEP164 Antibodies

AND CEP164 ELISA kits, CEP164 Proteins

Many biological assays use antibodies to detect CEP164, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CEP164 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CEP164 antibodies...

We validate the specificity of these antibodies to CEP164 by testing them on tissues known to express CEP164 positively and negatively. Browse below to find the CEP164 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CEP164 Infographic by Boster Bio

All CEP164 Products

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Anti-Centrosomal protein of 164 kDa CEP164 Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A05971
100ul

Anti-CEP164 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A05971-1
100 µg/vial

CEP164 Overview

Facts about Centrosomal protein of 164 kDa.

CEP164 3D structure. Source: alphafold

Centrosomal protein of 164 kDa (CEP164)

Plays a role in microtubule organization and/or upkeep for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a crucial role in G2/M checkpoint and nuclear divisions.

A vital player in the DNA damage-activated ATR/ATM signaling cascade because it is required for the correct phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a crucial role in chromosome segregation, acting as a mediator necessary for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.

Gene Information

Human
Gene Name:	CEP164
Uniprot:	Q9UPV0
Entrez:	22897

Family

Belongs to:

No superfamily

Alternative Names

centrosomal protein 164kDa; FLJ54767

Molecular Weight

Mass (kDA):
164.314 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (117316346..117413266)

Tissue Specificity

Expressed in several cell lines.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis. Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1.

Diseases

Ataxia
Genomic Instability
Ataxia Telangiectasia
Telangiectasis
Hepatitis, Chronic
Hepatitis C, Chronic
Familial Aplasia Of The Vermis
Carcinoma
Xeroderma Pigmentosum Complementation Group A
Fibrosis
Malignant Neoplasms
Neoplasms
Meckel-gruber Syndrome

Abnormal Degeneration
Hereditary Diseases
Liver Carcinoma
Hepatitis
Xeroderma
Malignant Paraganglionic Neoplasm
Xeroderma Pigmentosum

Interacting Proteins

CCDC92
DVL3
NPHP3
TTBK2

Pathways

Localization
Cell Cycle
Transport
Mitosis
Dna Repair
Intracellular Signal Transduction
Membrane Biogenesis
Chromosome Segregation
Response To Uv
Cell Death

Dna Damage Checkpoint
Sister Chromatid Cohesion
Interphase
Rna Interference
Chromatin Remodeling

PTMs

Phosphorylation

Prenylation

Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CEP164

References

PMID: 17954613 by Graser S., et al. Cep164, a novel centriole appendage protein required for primary cilium formation.

PMID: 18283122 by Sivasubramaniam S., et al. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.