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CENPA Antibodies
AND CENPA ELISA kits, CENPA Proteins
Many biological assays use antibodies to detect CENPA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CENPA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CENPA antibodies...
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CENPA Overview
Facts about Histone H3-like centromeric protein A.
Histone H3-like centromeric protein A (CENPA)
Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:7962047, PubMed:9024683, PubMed:11756469, PubMed:14667408, PubMed:15702419, PubMed:15475964, PubMed:15282608, PubMed:17651496, PubMed:19114591, PubMed:27499292, PubMed:20739937). Replaces conventional H3 in the nucleosome core of centromeric chromatin in the inner plate of the kinetochore (PubMed:18072184).
The existence of CENPA subtly modifies the nucleosome structure and how DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid in comparison to nucleosomes containing histone H3 (PubMed:27499292, PubMed:26878239). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15475964, PubMed:15282608, PubMed:26878239, PubMed:20739937, PubMed:21478274).
Gene Information
| Human | |
|---|---|
| Gene Name: | CENPA |
| Uniprot: | P49450 |
| Entrez: | 1058 |
Family
| Belongs to: |
|---|
| histone H3 family |
Alternative Names
Centromere autoantigen A; centromere protein A (17kD); centromere protein ACENP-Acentromere protein A, 17kDa; histone H3-like centromeric protein A
Molecular Weight
Mass (kDA):
15.991 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p23.3 |
| Sequence: | 2; NC_000002.12 (26786015..26794589) |
Subcellular Localizations
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height (PubMed:19114591). Phosphorylation at Ser-68 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location (PubMed:25556658).
Diseases
- Malignant Neoplasms
- Neoplasms
- Aneuploidy
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Autoimmune Reaction
- Sclerosis
- Intratubular Malignant Germ Cells
- Embryonal Carcinoma
- Seminoma
- Neoplasms, Germ Cell And Embryonal
- Diffuse Scleroderma
Interacting Proteins
- CENPC
- HIST1H4A
- HJURP
- MCM2
Pathways
- Cell Cycle
- Mitosis
- Spindle Checkpoint
- Anaphase
- Chromatin Organization
- Localization
- Cell Death
- Kinetochore Assembly
- Proteolysis
- Regulation Of Gene Expression
- Chromosome Segregation
- Centromere Binding
- Cell Division
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CENPA
bosterbio.com/bosterbio-gene-info-cards/CENPA
References
PMID: 7962047 by Sullivan K.F., et al. Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere.
PMID: 9024683 by Shelby R.D., et al. Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites.