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Centromere protein C Antibodies
AND CENPC ELISA kits, Centromere protein C Proteins
Many biological assays use antibodies to detect Centromere protein C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Centromere protein C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Centromere protein C antibodies...
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CENPC Infographic by Boster Bio
All CENPC Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A06766-1
100ul
Cat # A06766-1
100ul
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M06766-1
100 μl/vial
Cat # M06766-1
100 μl/vial
CENPC Overview
Facts about Centromere protein C.
Centromere protein C (CENPC)
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.
CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CENPC |
| Uniprot: | Q03188 |
| Entrez: | 1060 |
Family
| Belongs to: |
|---|
| CENP-C/MIF2 family |
Alternative Names
CENP-C 1; CENP-C; CENPCInterphase centromere complex protein 7; Centromere autoantigen C; centromere autoantigen C1; centromere protein C 1; hcp-4; ICEN7; MIF2
Molecular Weight
Mass (kDA):
106.834 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q13.2 |
| Sequence: | 4; NC_000004.12 (67468762..67545503, complement) |
Subcellular Localizations
Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Localizes exclusively in the kinetochore domain of centromeres.
Diseases
- Protein Truncation Abnormality
- Leukemia
- Carcinogenesis
Interacting Proteins
- CENPA
Pathways
- Methylation
- Cell Division
- Mitosis
- Kinetochore Assembly
- Metaphase
- Interphase
- Rna Processing
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CENPC
bosterbio.com/bosterbio-gene-info-cards/CENPC
References
PMID: 1339310 by Saitoh H., et al. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate.
PMID: 9645950 by Pluta A.F., et al. Interphase-specific association of intrinsic centromere protein CENP- C with HDaxx, a death domain-binding protein implicated in Fas- mediated cell death.