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- Table of Contents
Facts about CUGBP Elav-like family member 2.
Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not mature, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB.
Human | |
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Gene Name: | CELF2 |
Uniprot: | O95319 |
Entrez: | 10659 |
Belongs to: |
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CELF/BRUNOL family |
BRUNOL3ELAV-type RNA-binding protein 3; Bruno-like protein 3; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 2; CUG triplet repeat, RNA-binding protein 2; CUG-BP- and ETR-3-like factor 2; CUGBP Elav-like family member 2; CUGBP, Elav-like family member 2; CUG-BP2; CUGBP2hNAPOR; Etr-3; ETR3RNA-binding protein BRUNOL-3; NAPOR; NAPOR-2; Neuroblastoma apoptosis-related RNA-binding protein
Mass (kDA):
54.285 kDA
Human | |
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Location: | 10p14 |
Sequence: | 10; NC_000010.11 (10462515..11336675) |
Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas.
Nucleus. Cytoplasm. Accumulates in the cytoplasm after ionizing radiation (By similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
PMID: 9858671 by Choi D.-K., et al. Fluorescent differential display analysis of gene expression in apoptotic neuroblastoma cells.
PMID: 10524244 by Choi D.-K., et al. Developmentally-regulated expression of mNapor encoding an apoptosis- induced ELAV-type RNA binding protein.