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Cdnf Antibodies
AND Cdnf ELISA kits, Cdnf Proteins
Many biological assays use antibodies to detect Cdnf, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cdnf in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cdnf antibodies...
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Cdnf Infographic by Boster Bio
All Cdnf Products
Product
Figures
Specificity
Applications
Price
Rat
$250
Cat # PROTP0C5I0
5ug, 20ug, 1mg
Cat # PROTP0C5I0
5ug, 20ug, 1mg
Mouse
$250
Cat # PROTQ8CC36
5ug, 20ug, 1mg
Cat # PROTQ8CC36
5ug, 20ug, 1mg
Human
ELISA
$499
Cat # EK1656
96 wells/kit, with removable strips.
Cat # EK1656
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1657
96 wells/kit, with removable strips.
Cat # EK1657
96 wells/kit, with removable strips.
Human
Cell Culture
$77
Cat # PROTQ49AH0-2
5ug,20ug,100ug
Cat # PROTQ49AH0-2
5ug,20ug,100ug
Mouse
Cell Culture
$77
Cat # PROTQ8CC36-6
5ug,20ug,100ug
Cat # PROTQ8CC36-6
5ug,20ug,100ug
Cdnf Overview
Facts about Cerebral dopamine neurotrophic factor.
Cerebral dopamine neurotrophic factor (Cdnf)
Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons.
When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity). .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cdnf |
| Uniprot: | Q8CC36 |
| Entrez: | 227526 |
Family
| Belongs to: |
|---|
| ARMET family |
Alternative Names
arginine-rich, mutated in early stage tumors-like 1; ARMETL1; ARMET-like protein 1; CDNF; cerebral dopamine neurotrophic factor; Conserved dopamine neurotrophic factor
Molecular Weight
Mass (kDA):
21.032 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2|2 A1 |
| Sequence: | 2; |
Tissue Specificity
Expressed at high levels in the heart, skeletal muscle, testis and brain (at protein level). In the brain, detected in the cerebral cortex neurons through layers II to VI. In the hippocampus, detected in the CA1 to CA3 pyramidal regions and in the granule and polymorph layers of dentate gyrus. Weak expression in the striatum. In substantia nigra, detected in solitary cells that did not express tyrosine hydroxylase, a marker for dopaminergic neurons. Relatively high expression in the Purkinje cells of the cerebellum and in regions of the brain stem, including the locus coeruleus.
Diseases
- Parkinson Disease
- Neurodegenerative Disorders
- Nervousness
- Secondary Parkinson Disease
- Physiological Stress
- Abnormal Degeneration
- Nerve Degeneration
- Inflammation
- Cholangiocarcinoma
- Sclerosis
- Brain Ischemia
- Primary Lateral Sclerosis
Pathways
- Neuroprotection
- Pathogenesis
- Secretion
- Transport
- Glycosylation
- Localization
- Spermatogenesis
- Chondrocyte Proliferation
- Cell Death
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cdnf
bosterbio.com/bosterbio-gene-info-cards/Cdnf
References
PMID: 17611540 by Lindholm P., et al. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.