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- Table of Contents
Facts about Cyclin-dependent kinase 9.
Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g.
Human | |
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Gene Name: | CDK9 |
Uniprot: | P50750 |
Entrez: | 1025 |
Belongs to: |
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protein kinase superfamily |
C-2k; CDC2L4CTK1; CDC2-related kinase; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); cyclin-dependent kinase 9; EC 2.7.11; EC 2.7.11.22; EC 2.7.11.23; PITALRE; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; TAK
Mass (kDA):
42.778 kDA
Human | |
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Location: | 9q34.11 |
Sequence: | 9; NC_000009.12 (127786034..127790792) |
Ubiquitous.
Nucleus. Cytoplasm. Nucleus, PML body. Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated.
PMID: 8170997 by Grana X., et al. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.
PMID: 7695608 by Best J.L., et al. Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells.
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