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- Table of Contents
Facts about Cyclin-dependent kinase 7.
Each different complex controls a specific transition between two subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (although not complex formation).
Human | |
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Gene Name: | CDK7 |
Uniprot: | P50613 |
Entrez: | 1022 |
Belongs to: |
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protein kinase superfamily |
CAK1Xenopus laevis, cdk-activating kinase); CDK-activating kinase; Cell division protein kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7; EC 2.7.11; EC 2.7.11.22; EC 2.7.11.23; EC 2.7.11.24; p39 Mo15; serine/threonine kinase stk1,39 kDa protein kinase; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; TFIIH basal transcription factor complex kinase subunit
Mass (kDA):
39.038 kDA
Human | |
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Location: | 5q13.2 |
Sequence: | 5; NC_000005.10 (69234795..69277430) |
Ubiquitous.
Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
PMID: 7929589 by Tassan J.-P., et al. Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
PMID: 8208544 by Levedakou E.N., et al. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.