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- Table of Contents
Facts about Cadherin-related family member 5.
Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.
Human | |
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Gene Name: | CDHR5 |
Uniprot: | Q9HBB8 |
Entrez: | 53841 |
Belongs to: |
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No superfamily |
cadherin-related family member 5; CDHR5; FLJ20219; MUCDHL; MUCDHLmucin-like protocadherin; Mucin and cadherin-like protein; mucin and cadherin-like; MUPCDH; MU-PCDH; mu-protocadherin
Mass (kDA):
88.223 kDA
Human | |
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Location: | 11p15.5 |
Sequence: | 11; NC_000011.10 (616565..624967, complement) |
Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).
Apical cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein.
PMID: 11031102 by Paris M.J., et al. Characterization of a 500-kb contig spanning the region between c-Ha- Ras and MUC2 on chromosome 11p15.5.
PMID: 12167596 by Goldberg M., et al. Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys.