Cadherin-5 Antibodies

Cadherin-5 (CDH5)

They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a essential role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.

It partners with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.

Gene Information

Human
Gene Name:	CDH5
Uniprot:	P33151
Entrez:	1003

Family

Belongs to:
No superfamily

Alternative Names

7B4 antigen; 7B4; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144 antigen; CD144; CDH5; endothelial-specific cadherin; FLJ17376; Vascular endothelial cadherin; VECadherin; VE-Cadherin

Molecular Weight

Mass (kDA):
87.528 kDA

Genomic Context

Human
Location:	16q21
Sequence:	16; NC_000016.10 (66366657..66404784)

Tissue Specificity

Endothelial tissues and brain.

Subcellular Localizations

Cell junction. Cell membrane; Single-pass type I membrane protein. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions.

Diseases

• Tumor Angiogenesis
• Neoplasms
• Malignant Neoplasms
• Tissue Adhesions
• Carcinoma
• Pathologic Neovascularization
• Carcinogenesis
• Neoplasm Metastasis
• Hemorrhage
• Inflammation
• Acute Myocardial Infarction
• Infarction

• Tumor Progression
• Colonic Neoplasms
• Myocardial Infarction
• Atherosclerosis
• Diabetic Nephropathy
• Malignant Neoplasm Of Breast
• Polyps

Interacting Proteins

• CTNNB1
• PARD3
• PARD6A
• WARS

Pathways

• Angiogenesis
• Cell Adhesion
• Reverse Transcription
• Transdifferentiation
• Methylation
• Regulation Of Angiogenesis
• Cell Activation
• Tube Formation
• Glucose Homeostasis
• Translation
• Cell Cycle
• Cell Differentiation
• Regionalization

• Cell-cell Adhesion
• Cell Proliferation
• Endothelial Cell Activation
• Cell Development
• Vasculature Development
• Dna Methylation
• Blood Circulation

PTMs

• Methylation

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDH5

Best Uses Of The CDH5 Marker From Boster Bio

Boster Bio is a manufacturer of high-quality picogram sensitive ELISA kit and IHC-optimized monoclonal antibody. They have been thoroughly tested and come with a quality assurance. Find out more about these kits and how they can aid you.

Boster Bio is an antibody manufacturer that specializes in IHC-optimized polyclonal antibodies and picogram-sensitive ELISA kits.

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Boster Bio ELISA kits are tested and validated

Boster Bio offers a variety ELISA kits that have been validated against the CDH5 marker. They offer antibodies to the KHDRBS2 and CDH5 markers, as well as multiplex kits to detect these markers in various samples. Boster antibodies have been cited extensively in scientific publications and are trusted by researchers and labs. They can be examined using a variety of molecular and biochemical methods which include Western Blotting and ELISA.

Boster Bio ELISA Kits are guaranteed quality

Boster Bio ELISA kits contain all the reagents necessary to conduct success in an ELISA experiment. ELISA is a plate-based method where antibodies are linked with enzymes to identify and quantify molecules. There are different formats of ELISA and the principles behind their interactions vary. Boster's ELISA kit is designed to detect proteins in their natural forms and is tested against immunegenic proteins and superfamilies by Boster's QC department.

Boster Bio produces high-sensitivity and high-specificity ELISA kits with high-sensitivity and high-specificity. The antibodies have been extensively tested in a variety of applications such as WB, Flow Cymetry, IHC and ELISA. Over 29,000 publications have referenced Boster Bio products. Boster Bio ELISA Kits are protected by a quality guarantee. They are suggested for use in research and clinical settings. While certain ELISA kits may be more expensive, others could be more affordable.

The quality of an ELISA kit's preparation of the sample is the most significant factor. There are many ways to prepare samples to be used in ELISA or immunoassays. Different kinds of samples require different preparation techniques, which include special treatment. For those who are just beginning you can use the Boster Bio ELISA protocol provides step-by step instructions and serves as a reference. You can also use the Boster Bio protocol as a quick reference guide to improve your research.

Carbonic anhydrase 1, referred to as CA1, is an enzyme that has its genome located at 8q22. The protein contains 260 amino acids. It participates in a variety biological processes, including acid-base balance and respiration. It is a crucial component in the process of hydrating carbon dioxide. It is essential for respiration and calcification.

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