Cadherin-4 Antibodies

Cadherin-4 (CDH4)

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

May play an essential role in retinal development. .

Gene Information

Human
Gene Name:	CDH4
Uniprot:	P55283
Entrez:	1002

Family

Belongs to:
No superfamily

Alternative Names

CAD4; cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); Cadherin4; Cadherin-4; CDH4; FLJ22202; FLJ40547; MGC126700; MGC138355; RCAD; R-CAD; R-Cadherin; Retinal cadherin

Molecular Weight

Mass (kDA):
100.281 kDA

Genomic Context

Human
Location:	20q13.33
Sequence:	20; NC_000020.11 (61252261..61940617)

Tissue Specificity

Expressed mainly in brain but also found in other tissues.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Tissue Adhesions
• Neoplasms
• Malignant Neoplasms
• Nervousness
• Carcinoma
• Inflammation
• Stomach Neoplasms
• Cardiovascular Diseases
• Cholangiocarcinoma
• Malignant Bone Neoplasm
• Dementia
• Cardiac Hypertrophy

• Hypoxia
• Dyslexia
• Fibrosis
• Tumor Angiogenesis
• Chondrosarcoma
• Recurrence (disease Attribute)
• Ventricular Dysfunction, Left

Pathways

• Cell Adhesion
• Methylation
• Homophilic Cell Adhesion
• Cell-cell Adhesion
• Cell Proliferation
• Cell Death
• Transport
• Brain Development
• Aging
• Reverse Transcription
• System Development
• Axon Guidance
• Cell Cycle

• Cell Differentiation
• Cell Communication
• Intracellular Transport
• Cell-cell Recognition
• Response To Hypoxia
• Localization
• Regeneration

PTMs

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDH4

Best Uses of the CDH4 Marker

Researchers searching for CDH4 antibodies are in the right place. Boster produces high affinity primary antibodies, which have been widely used over the past 25 year. Their antibodies have been validated by the research community on Western Blotting, Immunohistochemistry, and ELISA. Boster is able to deliver antibodies of high affinity and specificity.

C2C2

The retina expresses CDH4 markers. It begins in the retina's ventronasal region and continues in a pattern controlled via hedgehog expression. CDH4 is an important factor in the differentiation and maintenance of different types of retinal cell types. This article will discuss some of the most popular uses of this marker in studying retinal development. Here are some of these uses:

The serum levels methylated NDG4 and SEPT9 were significantly higher among CRC patients than those in the controls. These results are encouraging, but further studies are needed to confirm them. Furthermore, a larger sample size, as well as studies with different ethnicities and other characteristics, are needed to confirm their predictive value. Some studies had short follow-up periods. Long-term evaluation of these biomarkers was therefore necessary.

There are many ways to detect cancer in human cells. One method is to do a CDH4 knockdown research. CDH4 knockdown promotes the growth of tumorigenesis in SACC83 cells. The growth curves of SACC-83 cells were monitored with a digital caliper at five days intervals for 36 days. Tumors were removed from nude mice, and examined for Ki67 expression. DAB40x was used to assess cell differentiation.

Studies have shown CDH4 is the receptor for Rcadherin. This gene plays an important role in skin health. Many patients with handfoot disorder have regulatory variants which prevent CDH4 from being expressed.

Another promising use for CDH4 methylation promoter is in diagnosis of gastric carcinoma. The promoter can be methylated to silence the CDH4 gene. In a mouse model, 5-aza-2-deoxycytidine restores the transcription of CDH4 gene. The CDH4 genome is methylated at 78% and 95% in colorectal, as well as in 95% of gastric cancers.

Studies have shown a link between low CDH4 levels in SACC tumours and reduced metastasis. This has implications for the use of CDH4 in SACC as a tumor suppressor. Further studies are required to determine the exact role that CDH4 plays in SACC. Therefore, CDH4 expression should be measured in cancer cell lines and tumors to confirm these findings. This marker is becoming more widely used in cancer research.

C2C1

The CDH4 Gene codes for the CDH4 protien. The CDH4 gene can be expressed by bacteria as well as human cells. It is found as part of the bacteria Leptotrichia Wadei F0279; Leptotrichia Acidoterrestris atCC 49025; and Bacillus Thermolovorans strains A4166.

The CDH4 gene can be found in cells of many different tissues and organs. Boster offers high-affinity prima antibodies derived from Eubacterium. They are tested and cited in research literature, ensuring their use and reliability. Boster antibodies are also tested for their performance in immunohistochemistry or Western blotting. They are highly sensitive and of high quality.