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Cadherin-23 Antibodies
AND Cdh23 ELISA kits, Cadherin-23 Proteins
Many biological assays use antibodies to detect Cadherin-23, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cadherin-23 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cadherin-23 antibodies...
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Cdh23 Overview
Facts about Cadherin-23.
Cadherin-23 (Cdh23)
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.
CDH23 is needed for establishing and/or keeping the correct organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the operational network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Cdh23 |
| Uniprot: | Q99PF4 |
| Entrez: | 22295 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
cadherin related 23; cadherin-23; cadherin-like 23; cadherin-related 23; cadherin-related family member 23; CDHR23; DKFZp434P2350; FLJ00233; FLJ36499; KIAA1774; KIAA1812; MGC102761; otocadherin; USH1D
Molecular Weight
Mass (kDA):
369.623 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 10 B4|10 30.11 cM |
| Sequence: | 10; |
Tissue Specificity
In adult animals relatively high levels of expression are found in testis, skeletal muscle, heart, eye and thymus, and lower expression in kidney, lung and brain. Found in the sensory hair cells of the inner ear.
Diseases
- Complete Hearing Loss
- Usher Syndrome
- Retinitis Pigmentosa
- Sensorineural Hearing Loss (disorder)
- Presbycusis
- Deafness Congenital
- Usher Syndrome, Type I
- Retinal Degeneration
- Noise-induced Hearing Loss
- Tissue Adhesions
- Retinal Diseases
Pathways
- Localization
- Transport
- Aging
- Cell Development
- Cell Adhesion
- Cell-cell Adhesion
- Pathogenesis
- Electron Transport
- Inner Ear Development
- Reflex
- Mrna Splicing
- Cell Differentiation
- Ear Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cdh23
bosterbio.com/bosterbio-gene-info-cards/Cdh23
References
PMID: 11138008 by Di Palma F., et al. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.
PMID: 11386759 by Wilson S.M., et al. Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice.