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CDCA7L Antibodies
AND CDCA7L ELISA kits, CDCA7L Proteins
Many biological assays use antibodies to detect CDCA7L, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDCA7L in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDCA7L antibodies...
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CDCA7L Overview
Facts about Cell division cycle-associated 7-like protein.
Cell division cycle-associated 7-like protein (CDCA7L)
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the complete transforming impact of MYC in medulloblastoma cells.
Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CDCA7L |
| Uniprot: | Q96GN5 |
| Entrez: | 55536 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
cell division cycle associated 7-like; DKFZp762L0311; JPO2cell division cycle-associated 7-like protein; Protein JPO2; R1HR1; RAM2; Transcription factor RAM2
Molecular Weight
Mass (kDA):
52.206 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p15.3 |
| Sequence: | 7; NC_000007.14 (21900899..21945899, complement) |
Tissue Specificity
Ubiquitous. Overexpressed in medulloblastoma.
Subcellular Localizations
Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Diseases
- Malignant Neoplasms
- Immunologic Deficiency Syndromes
- Hiv Infections
- Autoimmunity
- Neuroblastoma
- Cell Transformation, Neoplastic
- Oncogene Activation Process
- Glioblastoma
- Malignant Paraganglionic Neoplasm
- Brain Neoplasms
- Mental Disorders
- Cancer Patients And Suicide And Depression
Interacting Proteins
- ABT1
- BYSL
- CARD9
- CEP70
- CTNNBL1
- DAXX
- EIF4A3
- FAM9B
- ING5
- KRTAP10-7
Pathways
- Cell Death
- Methylation
- Protein Methylation
- Cell Proliferation
- Cell Cycle
- Apoptotic Signaling Pathway
- Mitosis
PTMs
- Sumoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDCA7L
bosterbio.com/bosterbio-gene-info-cards/CDCA7L
References
PMID: 15994933 by Huang A., et al. Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.
PMID: 15654081 by Chen K., et al. R1, a novel repressor of the human monoamine oxidase A.