Hsp90 co-chaperone Cdc37 Antibodies

Hsp90 co-chaperone Cdc37 (CDC37)

Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of the activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206).

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Gene Information

Human
Gene Name:	CDC37
Uniprot:	Q16543
Entrez:	11140

Family

Belongs to:
CDC37 family

Alternative Names

CDC37 (cell division cycle 37, S. cerevisiae, homolog); CDC37 cell division cycle 37 homolog (S. cerevisiae); CDC37 cell division cycle 37 homolog; CDC37A; cell division cycle 37 homolog (S. cerevisiae); Hsp90 chaperone protein kinase-targeting subunit; hsp90 co-chaperone Cdc37; P50CDC37

Molecular Weight

Mass (kDA):
44.468 kDA

Genomic Context

Human
Location:	19p13.2
Sequence:	19; NC_000019.10 (10391128..10403568, complement)

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Neoplasms
• Leukemia
• Malignant Paraganglionic Neoplasm
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Breast
• Carcinoma
• Melanoma
• Liver Carcinoma
• Prostatic Neoplasms
• Malignant Neoplasm Of Pancreas
• Malignant Neoplasm Of Prostate

• Myeloid Leukemia
• Mammary Neoplasms
• Growth Arrest
• Carcinogenesis
• Lymphoma
• Hepatocarcinogenesis
• Parkinson Disease

Interacting Proteins

• AKT1
• AKT3
• APOE
• AURKB
• CDK15

• CDK4
• CDK6
• CDK9
• CHUK
• CUL4B

• EGFR
• ERBB2
• FBXW2
• FER
• FKBP4

• HSP90AA1
• HSP90AB1
• IFIT3
• IKBKB
• IKBKE

• IKBKG
• KSR2
• LRRK2
• MAP3K14
• NOS3

• PDIK1L
• PPP5C
• PSEN1
• PSKH2
• RAF1

• SQSTM1
• STK11
• STK38L
• YES1
• ZNF843

Pathways

• Cell Cycle
• Cell Division
• Cell Proliferation
• Protein Folding
• Cell Growth
• Localization
• Pathogenesis
• Translation
• G1 Phase
• Cell Death
• Mitosis
• Rna Interference
• Autophagy

• Mating
• Oncogenesis
• Cell Cycle Arrest
• Induction Of Apoptosis
• Conjugation
• Cell Adhesion
• Flocculation

PTMs

• Phosphorylation
• Cleavage
• Ubiquitination

• Dephosphorylation
• Sumoylation
• Acetylation

• Methylation

Research Areas

• Cell Cycle and Replication
• Membrane Trafficking and Chaperones
• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC37

Best Uses Of The CDC37 Marker

Boster Bio is a company that provides a product for analyzing CDC37 mRNA. Boster Bio was established in 1993. It specializes in the manufacturing of antibodies and ELISA products that can be used in molecular biology experiments. Boster Bio recently expanded its product range to include PCR products. Boster Bio offers a range of services to scientists and researchers, in addition to its ELISA and antibody products. Boster Bio offers scientists free technical resources and a 24-hour technical support line.

IKBKB

Boster Bio Anti-CDC37 Antibodies are well-received by Humans and Mice. Picoband(tm), a Picoband(tm), contains 5 mg of bovine serum albumin. Boster Bio offers services that support scientists in their research, in addition to antibodies. Boster Bio provides technical support 24 hours per day. You can also access their technical resources free of charge. The CDC37 is one of the best proteins to use in various research settings.

The CDC37 proteins is found in human tissues. Biological assays that use the marker are extremely useful for diagnostic, research, and therapeutic purposes. Boster's high-affinity prima antibodies are well-respected and trusted by the scientific community. Boster's antibodies are validated on ELISA, Western Blotting, and Immunohistochemistry. It is easy to determine whether a particular protein is derived directly from an animal or a human-derived cell.

CDC37 Marker

One of the key characteristics of a proteins is its ability prevent nascent protein kinase chains being degraded by the proteasome. CDC37 is found within many proteins, including enzymes and kinases. Several of these proteins are found in human tissues, and the protein Cdc37 is crucial for their function.

The CDC37 protein is a member of a family of proteins called chaperones, which are involved in protein synthesis and refolding. The CDC37 protein appears regulate its activity under stress. Because of its importance to many biological processes, the CDC37 proteins is crucial in the diagnosis of cancers and other diseases. Cdc37 function has yet to be fully characterized.

The chaperone CDC37 protein is a chaperone that plays a critical role in cotranslational degradation. CDC37 reduces the amount of this protein by inhibiting HIPK2 expression. This effect is temporary, making it difficult for researchers to assess the impact of CDC37 on cancer and other diseases. Its presence in the bloodstream can lead to a variety of diseases and conditions, and CDC37 has been identified in cancer as well as in various organs.

Boster Bio

EMT is dependent on the CDC37 protein, which is an important component to a cell membrane. EMT must be successful if the protein is properly folded in the cell membrane. CDC37 binds to the proteins that are involved in the EMT. The protein functions in many pathways, including the cellcycle and Ras/Raf/MAPK pathways. It is important that you recognize the protein that can cause poor cell growth.

Rabbit and mouse

The CDC37 gene can be found in the C-terminal region mouse genomes. It has been linked to many human diseases. It has many important functions, including regulating apoptosis and preventing cancer. These functions are detectable using a variety of cell-based and molecular-based methods. The CDC37 gene can be detected with the help of a number of techniques including Southern hybridization and tetrad analysis.

The CDC37 genes is expressed on cells. It regulates the stability and activity of protein kinases. It is necessary for the stability, activity, and activation of Spc1MAPK in S.pombe. Cdc37 may function as a molecular messenger. Anti-myc immunoprecipitation is used to isolate Spc1 form the spc1 CDC37 HA6H spc1 strain. The myc epitope has been tagged onto the Cdc37+ sequences.

ICC

The CDC37 gene marker can be used for many purposes, including diagnostics and research. Boster Bio stocks many reagents or kits for this specific molecular mark. Boster Bio is a recognized antibody manufacturer. Boster Bio has a long line of signature products, including ELISA kits and antibody. They recently expanded their product range to include PCR-related molecular biology products. The company offers a full range of services for scientists and other researchers, including 24 hours customer support and technical resources.

Boster Bio offers the CDC37 antibody. Boster Bio stocks the CDC37 antibody. It reacts with human and rat sequences and can be stored at -20C or frozen for six month. It contains 5mg BSA (5mg) and 0.05mg Thimerosal (0.05mg). You can also get antibodies with blocking peptides that bind to a specific length of the immunogen.

Immunofluorescence

The CDC37 marker, which is highly immunogenic, is derived from human blood monoocytes. The protein can be used in a variety experiments to detect immune cell activation. Boster Bio offers high-affinity primary antibodies that have been validated on Western Blotting, Immunohistochemistry, and ELISA. Boster scientists discovered CDC37 in 2003. It has been extensively used in research since then.