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CDC25B Antibodies
AND CDC25B ELISA kits, CDC25B Proteins
Many biological assays use antibodies to detect CDC25B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDC25B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDC25B antibodies...
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CDC25B Infographic by Boster Bio
All CDC25B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9488
100 μg/vial
Cat # PB9488
100 μg/vial
Human, Rat
IHC, WB
$370
Cat # PA1546
100 μg/vial
Cat # PA1546
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC1980
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1980
1 kit, containing two 96-well plates and all necessary reagents
Human
ELISA
$540
Cat # EKC2233
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2233
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01899-1
100 μg/vial
Cat # A01899-1
100 μg/vial
CDC25B Overview
Facts about M-phase inducer phosphatase 2.
M-phase inducer phosphatase 2 (CDC25B)
Tyrosine protein phosphatase which acts as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner.
Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms appear to get a different level of activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | CDC25B |
| Uniprot: | P30305 |
| Entrez: | 994 |
Family
| Belongs to: |
|---|
| MPI phosphatase family |
Alternative Names
CDC25B; CDC25HU2; cell division cycle 25 homolog B (S. cerevisiae); cell division cycle 25 homolog B (S. pombe); cell division cycle 25B; Dual specificity phosphatase Cdc25B; EC 3.1.3.48; M-phase inducer phosphatase 2
Molecular Weight
Mass (kDA):
64.987 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p13 |
| Sequence: | 20; NC_000020.11 (3786772..3806121) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Esophageal Neoplasms
- Liver Carcinoma
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Neoplasm Metastasis
Interacting Proteins
- YWHAB
- YWHAG
- YWHAH
- YWHAZ
Pathways
- Cell Cycle
- Mitosis
- Cell Proliferation
- Cell Division
- Cell Cycle Arrest
- S Phase
- Cell Growth
- Localization
- Dna Replication
- G2 Phase
- Prophase
- M Phase
- Interphase
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Reduction
- Oxidation
Research Areas
- Cancer
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC25B
bosterbio.com/bosterbio-gene-info-cards/CDC25B
References
PMID: 1836978 by Galaktionov K.I., et al. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins.
PMID: 1662986 by Nagata A., et al. An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells.