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CDC16 Antibodies
AND CDC16 ELISA kits, CDC16 Proteins
Many biological assays use antibodies to detect CDC16, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CDC16 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CDC16 antibodies...
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CDC16 Infographic by Boster Bio
All CDC16 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$540
Cat # EKC2285
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2285
1 kit, containing two 96-well plates and all necessary reagents
CDC16 Overview
Facts about Cell division cycle protein 16 homolog.
Cell division cycle protein 16 homolog (CDC16)
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
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Gene Information
| Human | |
|---|---|
| Gene Name: | CDC16 |
| Uniprot: | Q13042 |
| Entrez: | 8881 |
Family
| Belongs to: |
|---|
| APC6/CDC16 family |
Alternative Names
ANAPC6subunit 6; CDC16 (cell division cycle 16, S. cerevisiae, homolog); CDC16 cell division cycle 16 homolog (S. cerevisiae); CDC16 homolog; CDC16Hs; cell division cycle 16 homolog (S. cerevisiae); cell division cycle protein 16 homolog; Cyclosome subunit 6
Molecular Weight
Mass (kDA):
71.656 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q34 |
| Sequence: | 13; NC_000013.11 (114234845..114272723) |
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Diseases
- Malignant Neoplasms
- Neoplasms
- Melanoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Liver Carcinoma
- Chromosomal Translocation
- Liver Neoplasms
- Insulin Resistance
- Nervousness
- Cytogenetic Abnormality
- Neuroblastoma
Interacting Proteins
- CDC26
Pathways
- Cell Cycle
- Mitosis
- Anaphase
- Cytokinesis
- Cell Division
- Exit From Mitosis
- Transport
- Proteolysis
- Metaphase
- Localization
- Interphase
- Dna Replication
- S Phase
PTMs
- Ubiquitination
- Phosphorylation
Research Areas
- Cell Biology
- Cell Cycle and Replication
- Phospho-Specific
- Ubiquitin Proteasome Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDC16
bosterbio.com/bosterbio-gene-info-cards/CDC16
References
PMID: 7736578 by Tugendreich S., et al. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition.
PMID: 9405394 by Ollendorff V., et al. The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase- promoting complex.