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SLAM family member 5 Antibodies
AND CD84 ELISA kits, SLAM family member 5 Proteins
Many biological assays use antibodies to detect SLAM family member 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLAM family member 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLAM family member 5 antibodies...
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CD84 Overview
Facts about SLAM family member 5.
SLAM family member 5 (CD84)
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and are involved in the regulation and interconnection of both innate and adaptive immune reaction.
Tasks are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity determined by SH2D1A and SH2D1B (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | CD84 |
| Uniprot: | Q9UIB8 |
| Entrez: | 8832 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD84 antigen (leukocyte antigen); CD84 antigen; CD84 molecule; CD84; Cell surface antigen MAX.3; DKFZp781E2378; hCD84; hly9-beta; leucocyte differentiation antigen CD84; leukocyte antigen CD84; Leukocyte differentiation antigen CD84; Ly-9B; mCD84; Signaling lymphocytic activation molecule 5; SLAM family member 5; SLAMF5; SLAMF5LY9B
Molecular Weight
Mass (kDA):
38.782 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.3 |
| Sequence: | 1; NC_000001.11 (160541094..160579516, complement) |
Tissue Specificity
Predominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells. Expressed in mast cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Lymphoproliferative Disorders
- X-linked Lymphoproliferative Disorders
- Immunologic Deficiency Syndromes
- Autoimmunity
- Tissue Adhesions
- Lupus Erythematosus, Systemic
- Neoplasms
- Epstein-barr Virus Infections
- Autoimmune Reaction
- Primary Immune Deficiency Disorder
- Autoimmune Diseases
- Infectious Mononucleosis
- Lymphoma
Interacting Proteins
- SH2D1B
Pathways
- Lymphocyte Activation
- Secretion
- Cell Activation
- Leukocyte Activation
- Germinal Center Formation
- Immune Response
- Pathogenesis
- Cell Adhesion
- T Cell Activation
- Cytokine Secretion
- Platelet Aggregation
- Cell Maturation
- Chromosome Localization
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD84
bosterbio.com/bosterbio-gene-info-cards/CD84
References
PMID: 9310491 by de la Fuente M.A., et al. CD84 leukocyte antigen is a new member of the Ig superfamily.
PMID: 10698700 by Krause S.W., et al. Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84.