CD80 Antibodies

T-lymphocyte activation antigen CD80 (CD80)

Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

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Gene Information

Human
Gene Name:	CD80
Uniprot:	P33681
Entrez:	941

Family

Belongs to:
No superfamily

Alternative Names

Activation B7-1 antigen; B7; B71; B7-1; BB1; CD28LG1; CD28LGB7-1 antigen); CD80 antigen; CD80 molecule; CD80; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; T-lymphocyte activation antigen CD80

Molecular Weight

Mass (kDA):
33.048 kDA

Genomic Context

Human
Location:	3q13.33
Sequence:	3; NC_000003.12 (119524293..119559614, complement)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Neoplasms
• Malignant Neoplasms
• Autoimmune Reaction
• Inflammation
• Tissue Adhesions
• Autoimmune Diseases
• Carcinoma
• Leukemia
• Decreased Immunologic Activity [pe]
• Autoimmunity
• Melanoma
• Lymphoma

• Malignant Paraganglionic Neoplasm
• Infective Disorder
• Arthritis
• Hiv Infections
• Immunologic Deficiency Syndromes
• Neoplasm Metastasis
• Myeloid Leukemia

Interacting Proteins

• CD274
• CTLA4
• NGFR

Pathways

• Immune Response
• Cell Activation
• Secretion
• Cell Proliferation
• T Cell Activation
• Cytokine Production
• T Cell Proliferation
• Pathogenesis
• Cell Differentiation
• Hypersensitivity
• Cell Maturation
• Cytokine Secretion
• Cell Death

• Sensitization
• Phagocytosis
• Endocytosis
• Localization
• Lymphocyte Proliferation
• Tolerance Induction
• Cell Adhesion

PTMs

• Phosphorylation
• Glycosylation
• Methylation
• Cleavage
• Acetylation
• Reduction
• Biotinylation
• Ribosylation
• Acylation
• Myristoylation

• Demethylation
• Phosphorothioation
• Prenylation
• Ubiquitination
• Nitration
• Geranylgeranylation
• Carboxylation
• Dephosphorylation
• Farnesylation
• Palmitoylation

Research Areas

• Adaptive Immunity
• Cytokine Research
• Immunology
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD80

Best Uses Of The CD80 Marker

If you're interested in Boster Bio and how to make use of it then you've come to the right site. This article will explain the workflow and protocol for this unique immunoassay. We will also look at the various uses of this CD80 marker for human diseases. Continue reading to learn more! *The Best Uses for The CD80 Marker

BosterBio

Anti-CD80 antibodies can be purchased from several suppliers. These antibodies target human CD80 which is also known as B71 or B7-1. They are also known as BB1. The gene itself is 33 kilodaltons mass and could also have canine, porcine , and mouse orthologs. It is possible to purchase blocking peptides when you are searching for an specific antibody.

The CD80 marker is a biomarker crucial in inflammatory diseases. It is used by researchers to discover if certain cells are involved for the development of arthritis as well as other ailments. The protein is also found in activated B cells, and is believed to give an energizing signal to T cells. CD80 is a receptor for two surface proteins on the T cell's surfaces, CD28 and CTLA-4. It can be used in combination with CD86 to activate T cells.

RhuDex(tm), inhibits DTH in Rhesus monkeys. RhuDex(tm) blocks the major inflammatory cells (TNF-a) while also reducing the production of IL-2 in the same way as the control group. The product blocks proliferation better than anti-CD80 monoAb. Although the company doesn't provide specific to humans CD80 antibodies for research purposes However, they do sell these products.

BosterBio workflow

The Boster Bio CD80 workflow is a step-bystep guide that outlines the exact steps to perform an immunostaining test. It also lists suggested reagents as well as sample preparation and optimization techniques. These protocols can be utilized by researchers in industrial and academic settings , and are designed to increase reproducibility and productivity. The CD80 antibody is available as a separate item and is available from bosterbio.com or from your local BosterBio reseller.

BosterBio protocol

The BosterBio protocol for the use of the CD80 antibody is an IHC kit that can detect a range of cytokines and hormones which include IL-6 and IL-8. It has been tested on various samples, and includes enough reagents for you to run tests of 96. The kit includes the reagents needed to detect an array of other proteins such as EGF, HSP70, and various Cytokines.

ELISA requires a variety of decisions such as how to prepare samples. It is crucial to select the right buffer for blocking and have the antibodies at the highest concentration. The Boster Bio optimization guides and guidelines will help you make the right decision. In the end, you'll have a high-quality, accurate result using the BosterBio CD80 antibody protocol. If you're not sure seek out an expert to find out more about the protocol.

The BosterBio procedure for the use of the CD80 antibody is a wonderful method of confirming that your T cells are activated. It is a costimulatory signal for T cells that works with the B7-1 protein. It attaches to CD86 and CD80 T cell surface proteins that prime T cells to activate. This protocol makes use of BosterBio antibodies that have been validated and improved by BosterBio.