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CD5 antigen-like Antibodies
AND CD5L ELISA kits, CD5 antigen-like Proteins
Many biological assays use antibodies to detect CD5 antigen-like, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD5 antigen-like in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD5 antigen-like antibodies...
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CD5L Infographic by Boster Bio
All CD5L Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$499
Cat # EK1413
96 wells/kit, with removable strips.
Cat # EK1413
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # EK1414
96 wells/kit, with removable strips.
Cat # EK1414
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK1413
96 wells/kit, with removable strips.
Cat # FEK1413
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # FEK1414
96 wells/kit, with removable strips.
Cat # FEK1414
96 wells/kit, with removable strips.
CD5L Overview
Facts about CD5 antigen-like.
CD5 antigen-like (CD5L)
Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Following incorporation into mature adipocytes via CD36-mediated endocytosis, partners with cytosolic FASN, inhibiting fatty acid synthase activity and resulting in lipolysis, the degradation of triacylglycerols to glycerol and free fatty acids (FFA).
CD5L-induced lipolysis occurs with development of obesity: participates in obesity-associated inflammation after recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity- related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC).
Gene Information
| Human | |
|---|---|
| Gene Name: | CD5L |
| Uniprot: | O43866 |
| Entrez: | 922 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AIM; API6; apoptosis inhibitor 6; CD5 antigen-like (scavenger receptor cysteine rich family); CD5 antigen-like; CD5 molecule-like; CD5L; CT-2; IgM-associated peptide; PRO229; Spalpha; SP-alpha
Molecular Weight
Mass (kDA):
38.088 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q23.1 |
| Sequence: | 1; NC_000001.11 (157827068..157841844, complement) |
Tissue Specificity
Expressed in spleen, lymph node, thymus, bone marrow, and fetal liver, but not in non-lymphoid tissues.
Subcellular Localizations
Secreted. Cytoplasm. Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported in the cytoplasm via CD36-mediated endocytosis (By similarity).
Diseases
- Inflammation
- Pneumonia
- Metabolic Diseases
- Obesity
- Lung Diseases
- Malignant Neoplasms
- Liver Cirrhosis
- Hepatitis C, Chronic
- Fibrosis
- Pulmonary Emphysema
- Lymphoma
- Chronic Inflammation
- Hepatitis
Pathways
- Pathogenesis
- Cell Growth
- Secretion
- Cell Activation
- Cell Proliferation
- T Cell Activation
- Immune Response
- B Cell Proliferation
- Cell Adhesion
- Chemokine Production
- Glycosylation
- Dna Repair
- Endocytosis
PTMs
- Phosphorylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD5L
bosterbio.com/bosterbio-gene-info-cards/CD5L
References
PMID: 9045627 by Gebe J.A., et al. Molecular cloning, mapping to human chromosome 1 q21-q23, and cell binding characteristics of Spalpha, a new member of the scavenger receptor cysteine-rich (SRCR) family of proteins.
PMID: 8034987 by Tissot J.-D., et al. Two-dimensional polyacrylamide gel electrophoresis analysis of cryoglobulins and identification of an IgM-associated peptide.