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- Table of Contents
1 Citations 9 Q&As
2 Citations 3 Q&As
15 Q&As
1 Citations 16 Q&As
Facts about Tumor necrosis factor receptor superfamily member 5.
Receptor for TNFSF5/CD40LG.
Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, resulting in induction of immunoglobulin secretion..
Human | |
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Gene Name: | CD40 |
Uniprot: | P25942 |
Entrez: | 958 |
Belongs to: |
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No superfamily |
B cell surface antigen CD40; B-cell surface antigen CD40; Bp50B cell-associated molecule; CD40 antigen; CD40 molecule, TNF receptor superfamily member 5; CD40 type II isoform; CD40; CD40L receptor; CDw40; MGC9013; nerve growth factor receptor-related B-lymphocyte activation molecule; p50; TNFRSF5; TNFRSF5CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily, member 5
Mass (kDA):
30.619 kDA
Human | |
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Location: | 20q13.12 |
Sequence: | 20; NC_000020.11 (46118242..46129858) |
B-cells and in primary carcinomas.
[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.
PMID: 2475341 by Stamenkovic I., et al. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.
PMID: 11172023 by Tone M., et al. Regulation of CD40 function by its isoforms generated through alternative splicing.
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