CD209 antigen Antibodies

CD209 antigen (CD209)

Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune reaction. Thought to mediate the endocytosis of pathogens that are subsequently degraded in lysosomal compartments.

The receptor returns to the cell membrane surface and the pathogen-derived antigens are introduced to resting T-cells through MHC class II proteins to initiate the adaptive immune reaction. .

Gene Information

Human
Gene Name:	CD209
Uniprot:	Q9NNX6
Entrez:	30835

Family

Belongs to:
No superfamily

Alternative Names

CD209 antigendendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbingnon-integrin; CD209 molecule; CD209; CDSIGNHIV gpl20-binding protein; CLEC4L; CLEC4LC-type lectin domain family 4 member L; DCSIGN; DC-SIGN; DC-SIGN1; DC-SIGN1C-type lectin domain family 4, member L; DC-SIGNMGC129965; Dendritic cell-specific ICAM-3-grabbing non-integrin 1

Molecular Weight

Mass (kDA):
45.775 kDA

Genomic Context

Human
Location:	19p13.2
Sequence:	19; NC_000019.10 (7739993..7747609, complement)

Tissue Specificity

Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 4]: Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Cell membrane; Single-pass type II membrane protein.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.; [Isoform 9]: Secreted.; [Isoform 10]: Secreted.; [Isoform 11]: Secreted.; [Isoform 12]: Secreted.

Diseases

• Tissue Adhesions
• Hiv Infections
• Tuberculosis
• Inflammation
• Neoplasms
• Dengue Fever
• Malignant Neoplasms
• Immunologic Deficiency Syndromes
• Tuberculosis, Pulmonary
• Virus Diseases
• Innate Immune Response
• Infective Disorder
• Mycoses

• Hepatitis
• Hemorrhagic Fevers, Viral
• Dengue Hemorrhagic Fever
• Hepatitis C
• Communicable Diseases
• Lymphoma
• Sclerosis

Interacting Proteins

• VAC14

Pathways

• Immune Response
• Pathogenesis
• Secretion
• Phagocytosis
• Endocytosis
• Cell Proliferation
• T Cell Proliferation
• Cell Differentiation
• Glycosylation
• Inflammatory Response
• Innate Immune Response
• Cell Adhesion
• Macrophage Activation

• Dendritic Cell Differentiation
• Localization
• Cytokine Production
• Monocyte Differentiation
• Viral Replication
• Cell Activation
• Tropism

PTMs

• Phosphorylation
• Glycosylation
• Methylation
• Deglycosylation

• Demethylation
• Cleavage
• Citrullination
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD209

Best Uses of the CD209 Marker

If you're interested in Boster Bio, CD209, or DC-SIGN (Pathogen Receptor on Dendritic Cells), read on! We'll go over the most effective uses of this marker and Boster Bio's products, and explain why you should use the markers in your research. The best uses of this marker go beyond the detection of the presence of immune cells. they also help in assessing the effects of illness on the body.

Boster Bio

The CD209 marker is a frequent target for cancer immunotherapy. It is located on the surface of many types of cancer cells such as T cells and B cells. Boster Bio scientists are able to provide results for specific species, samples and applications to gain from credits for product development. This marker is available to scientists of all disciplines and from any country. Here are some of the most useful uses for this marker:

The CD209 marker can bind to a variety molecules such as the gp120 protein in HIV. The antigen is also present on the surface of dendritic cells. This molecule is used by dendritic cells to recognize pathogens. Through the MHC class II proteins, antigens from pathogens can be introduced to resting T-cells.

CD209

CD209 is an antigen of the cell surface that is expressed on immature dendritic cells. It also functions as a pathogen receptor. Antibodies derived from various animal species can recognize the antigen. Boster Bio produces its antibodies against this antigen by using mice and rabbits. Through MHC class II proteins, pathogen-derived antigens can be introduced to resting T cells.

The CD209 molecules, which is a 45-kDa transmembrane type-2 transmembrane proteins belonging to the C lectin family that is 45-kDa. It is expressed on myeloid cells and is involved in the movement and interaction of dendritic cells in the presence of naive T lymphocytes. CD209 is made up of a C type lectin-like domain and a multisection stalk. It also has an cell cytoplasmic tail. The cytoplasmic tail forms a part of the internalization motif in humans.

CD209 can be used to determine whether cancer cells are responding to a medication or vaccine. Boster Bio's mDC technology lets researchers examine the immune responses of cells to TNF-a. The mDCs that express CD11c have a higher affinity for CD209 than T cells.

DC-SIGN (Pathogen Receptor on Dendritic Cells)

The CD209 marker, a type 2 transmembrane protein, 45 kDa, is part of the C lectin family. It is expressed on myeloid dendritic cell and is involved in the migration of these cells and in their interactions with T lymphocytes of the naive. The protein's structure is comprised of an C type lectin-like domain and a multi-section stalk. It also has a terminal cytoplasmic tail. In humans, this molecule is in contact with the MHC class II proteins CD4, CD25, and MHC class II.

The Boster Bio platform has a number of guides to optimize experiments and eliminate potential error sources. Many of these guides are extremely helpful in guiding your decision-making and optimizing experiments to increase your results. Every researcher has experienced an issue with their research. There are a variety of causes for error. However Boster bio troubleshooting manual can help you find and fix any problems. This will prevent you from spending your time and money.

The CD209 marker is vital in immunodiagnosis, disease modeling, and other aspects of determining the cause of an illness. It assists in identifying the immune cells that are responsible for the onset of inflammation. It can help identify the immune system components that are responsible for this condition and help with treatment options. It can also be used to determine if an anti-inflammatory medicine works well in an individual's system. There are a number of reasons for why CD209 markers are so vital.

These antigens target DCs. Their capability to target DCs was tested using phage display libraries. To screen binding peptides in vivo or in cells, using phage display libraries. These antigens were chosen randomly. Certain phages can only bind to marrow cells. others connect to chBMDCs in greater proportion.

The use of DCs could improve poultry vaccines. The chicken's immune system is believed to have evolved to adapt to their environment. DCs are immune cells that detect and recognize antigens. The immune response they elicit is mediated by B cells and T cells, and DCs release antigens directly to lymphocytes. The cells then migrate to the peripheral region.

Anti-human CD209 antibody

The Boster Bio Anti-BioSIG/CD209 Antibody is part of their Picoband(tm) catalog. It reacts with Human, Mouse, and Rat and has been tested in WB applications. You can also purchase a blocking peptide. This anti-CD209 antigen is ideal for Immunofluorescence studies or cell-based tests and more.

CD209 is a member the C-type lectin family. The protein is found on dendritic cells and macrophages, two types each of white blood cells. It plays a role in the innate immune system as well as in facilitating dendritic cells' migration. It also recognizes HIV-1 and acts as an agonist for LSP1 the lectin carbohydrate-binding protein.

The Human CD209 ELISA kit from Boster Bio contains 96-well plates and strips that can be removed for up to 96 samples. The kit measures Human CD209 in serum and supernatants of cell culture and has an sensitivity of 10 mg/ml. The kit does not cross-reactivity with other relevant proteins. It is an effective instrument for researchers researching dengue.

Human anti-hDEC205 antibodies were developed by using 3D6 and 3G9. Both mAbs bind hDEC205 as well as NLDC145. The highest affinity for the hDEC205 protein was observed in mAbs 3D6 (and 3G9). Western blotting confirmed the epitope of the fusion mAb on hDEC205.