Cct5 Antibodies

T-complex protein 1 subunit epsilon (Cct5)

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia.

Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). .

Gene Information

Mouse
Gene Name:	Cct5
Uniprot:	P80316
Entrez:	12465

Family

Belongs to:
TCP-1 chaperonin family

Alternative Names

chaperonin containing TCP1, subunit 5 (epsilon); epsilon subunit

Molecular Weight

Mass (kDA):
59.624 kDA

Genomic Context

Mouse
Location:	15|15 B2
Sequence:	15;

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Breast
• Carcinoma
• Mammary Neoplasms
• Sensory Neuropathy
• Lymphatic Metastasis
• Stomach Neoplasms
• Neoplasm Metastasis
• Metastatic Malignant Neoplasm To The Lymph Node
• Malignant Tumor Of Colon
• Enterovirus Infections

• Pain
• Anhidrosis
• Esophageal Neoplasms
• Hereditary Sensory And Autonomic Neuropathies
• Adenocarcinoma
• Neoplasm Recurrence, Local

Pathways

• Translation
• Transport
• Cell Adhesion
• Brain Development
• Oocyte Maturation
• Embryo Development
• Drug Resistance
• Reverse Transcription
• Cell Death
• Cell Motility

• Cell Cycle
• Cell Differentiation
• Cell Growth
• Pathogenesis

PTMs

• Acetylation
• Isopeptide bond

• Phosphoprotein
• Ubl conjugation

Research Areas

• Core ESC-Like Genes
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cct5

Best Uses Of The CCT5 Marker

The CCT5 marker is a biomarker that can be used for diagnostics and clinical research. It can be neutralized with neutralizing antibodies. These are known as anti-CCL5 metabolites. Boster scientists across the globe have access to neutralizing antibodies against CCL5.

CCL5 Marker

The Boster Bio AntiMCP/CXCL9 antigen reacts to mouse CXCL9, which is a member the CXC Chemokine Family. CXCL9 antibody can be used to increase chemokine production and activate integrins. These antibodies can also be used for TCM peripherization.

CCR5 functions as an HIV coreceptor. This is how HIV enters cells and spreads from one cell to another. Despite being rare during early infection, CXCR4 strains are known to be present in human cells. CCR5 receptor-targeting immunogens are designed for eliciting both mucosal as well as systemic immune responses. HIV therapy focusing on CCR5/RANTES is a possible strategy to reduce the spread of the virus.

The CCR5 chemokine receptor, also known as CCR5, is expressed on a variety of cell types. CCR5 is expressed by immune synapses as a costimulatory molecule. CCR5 not only orchestrates cellular immunity but also induces activation markers to primary T cells. CCL5 increases the proliferative response to CD4+ T cell and supports recruitment of naive, CD8+ T cell clusters to dendritic cells.

Arginine Metabolite

Arginine is one of the most widely studied compounds in the body. Despite its complex metabolism, the findings suggest that it may be involved in cardiovascular disease. Molecular structures and references are shown in Table 1. Table 1 lists references and molecular structures. Arginine levels in blood are generally in the 100-mM range, but intracellular concentrations can be much higher. However, the exact pathways of arginine synthesis and degradation remain unclear.

Arginine loss reduced osteoclast formation, but not completely. Resupplying arginine can compensate for the loss of osteoclast formation by increasing recArg1. The essential intermediates for osteoclast development are vital because bone remodeling relies heavily on arginine. These intermediates can be produced by the body in a dynamic metabolic adaption to maintain cell fitness. Moreover, they are used in a variety of fields of biomedicine, including bone remodeling.

It is possible to study arginine metabolism using reagents, which inhibit the synthesis by the kidney. Recombinant Arginase synthase is involved in arginine metabolism. Mutations in the enzyme can cause cell death and the production putrescine. Consequently, the effects of arginine depletion in the kidneys and liver are currently unknown.

It is also known that arginine deficiency can affect the absorption nutrients. For example, arginine deficiencies in plants can cause inhibitions in the activity four enzymes, including ammonium transporter or ammonium assimilation. These inhibitions are relieved by exogenous Argonine, which allows for normal growth and development. However, plants can suffer from a variety of negative effects if they are deficient in N.

PLC Neutralization

Bosterbio.com offers neutralizing antibodies against CCL5 chemokine. The antibodies can react with Cct5 on a variety animals. Boster Bio uses rabbit and mouse to develop these antibodies. The CCL5 marker may be a subunit in the T-complex Protein that plays a role in assembly of the complex BBSome and ciliogenesis.

Clinical applications

The CCR5 gene and its related protein are characterized. Polymorphisms of the gene are discussed, as are the evolutionary implications of the CCR5D32 variant. CCR5 plays a role in fungal disease. New studies on CCR5 and regulatory cells T cells are also discussed. Finally, a discussion is given of the CCR2-CCR5 gene region. It is not clear whether this polymorphism affects monocytes directly.