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- Table of Contents
Facts about Trace amine-associated receptor 5.
Trimethylamine is a bacterial metabolite found in certain animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food. This receptor is likely mediated by the G(s)-course of G-proteins which activate adenylate cyclase.
Human | |
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Gene Name: | TAAR5 |
Uniprot: | O14804 |
Entrez: | 9038 |
Belongs to: |
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G-protein coupled receptor 1 family |
MGC138414; MGC138416; PNRRP11-295F4.5; Putative neurotransmitter receptor; taR-5; trace amine associated receptor 5; Trace amine receptor 5; trace amine-associated receptor 5
Mass (kDA):
38.242 kDA
Human | |
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Location: | 6q23.2 |
Sequence: | 6; NC_000006.12 (132588592..132589738, complement) |
Expressed almost exclusively in skeletal muscle and selected areas of the brain, such amygdala, hippocampus, caudate nucleus, thalamus and hypothalamus. Weak expression is also find in substantia nigra.
Cell membrane; Multi-pass membrane protein.
PMID: 9464258 by Zeng Z., et al. Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain.
PMID: 15718104 by Lindemann L., et al. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.