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- Table of Contents
2 Citations 15 Q&As
1 Citations 16 Q&As
Facts about C-C chemokine receptor type 2.
Receptor for the CCL2, CCL7 and CCL12 chemokines (PubMed:8996246).
Receptor for the beta-defensin DEFB106A/DEFB106B (By similarity).Transduces a signal by increasing intracellular calcium ion levels (PubMed:8996246). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity).
Mouse | |
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Gene Name: | Ccr2 |
Uniprot: | P51683 |
Entrez: | 12772 |
Belongs to: |
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G-protein coupled receptor 1 family |
C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-R; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Mass (kDA):
42.783 kDA
Mouse | |
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Location: | 9 F4|9 75.05 cM |
Sequence: | 9; |
Detected in monocyte/macrophage cell lines, but not in nonhematopoietic cell lines.
If you are looking for an antibody, you may be wondering what Boster Bio Anti-Macrosialin CD68 Antibody is and what it can do for you. The company started in 1993 and specializes in antibody manufacturing. It has recently expanded its offerings to include PCR-related molecular biology products. In addition to offering quality antibodies, Boster Bio provides a wide range of services for scientists. Technical resources and free technical support are also provided to customers.
The anti-Macrosialin CD68 antibody is a 110 kD transmembrane glycoprotein highly expressed in human monocytes and tissue macrophages. It belongs to the family of mucin-like molecules and has a genome-wide position of 17p13.1. It is a very useful marker of macrophage lineage and helps differentiate various diseases, even though their cellular appearance is similar.
PMID: 8631787 by Boring L., et al. Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.
PMID: 8662823 by Kurihara T., et al. Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC.
*More publications can be found for each product on its corresponding product page