CCP110 Antibodies

AND CCP110 ELISA kits, CCP110 Proteins

Many biological assays use antibodies to detect CCP110, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCP110 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCP110 antibodies...

We validate the specificity of these antibodies to CCP110 by testing them on tissues known to express CCP110 positively and negatively. Browse below to find the CCP110 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCP110 Infographic by Boster Bio

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Anti-CP110/CCP110 Antibody Picoband®

13 Q&As

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A05058-1
100 μg/vial

CCP110 Overview

Facts about Centriolar coiled-coil protein of 110 kDa.

CCP110 3D structure. Source: alphafold

Centriolar coiled-coil protein of 110 kDa (CCP110)

Necessary for centrosome duplication at different phases of procentriole formation. Acts as a key negative regulator of ciliogenesis in cooperation with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064).

Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the combination of recycling endosomes to basal bodies during cilia formation (By similarity).

Gene Information

Human
Gene Name:	CCP110
Uniprot:	O43303
Entrez:	9738

Family

Belongs to:

No superfamily

Alternative Names

centriolar coiled coil protein 110kDa; Cep110; CP110

Molecular Weight

Mass (kDA):
113.424 kDA

Genomic Context


Human

Location:	16p12.3
Sequence:	16; NC_000016.10 (19523879..19553408)

Tissue Specificity

Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact.

Interacting Proteins

CCNF
CEP290
CEP97
CETN2
KIF24

NEURL4

PTMs

Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCP110

References

PMID: 12361598 by Chen Z., et al. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.

PMID: 16760425 by Tsang W.Y., et al. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.