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CCN family member 1 Antibodies
AND CCN1 ELISA kits, CCN family member 1 Proteins
Many biological assays use antibodies to detect CCN family member 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCN family member 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCN family member 1 antibodies...
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CCN1 Infographic by Boster Bio
All CCN1 Products
Product
Figures
Specificity
Applications
Price
Human CYR61/CCN1 ELISA Kit PicoKine®
1 Citations 6 Q&As
Human
ELISA
$750
Cat # EK1203
96 wells/kit, with removable strips.
Cat # EK1203
96 wells/kit, with removable strips.
CCN1 Overview
Facts about CCN family member 1.
CCN family member 1 (CCN1)
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5.
CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1.
Gene Information
| Human | |
|---|---|
| Gene Name: | CCN1 |
| Uniprot: | O00622 |
| Entrez: | 3491 |
Family
| Belongs to: |
|---|
| CCN family |
Alternative Names
CCN family member 1; CCN1; CCN1IGF-binding protein 10; Cyr61; Cysteine-rich angiogenic inducer 61; cysteine-rich, angiogenic inducer, 61; GIG1; GIG1cysteine-rich heparin-binding protein 61; IBP-10; IGFBP-10; IGFBP10cysteine-rich, anigogenic inducer, 61; Insulin-like growth factor-binding protein 10; protein CYR61; Protein GIG1
Molecular Weight
Mass (kDA):
42.027 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.3 |
| Sequence: | 1; NC_000001.11 (85580761..85583950) |
Subcellular Localizations
Secreted.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Tumor Angiogenesis
- Carcinoma
- Pathologic Neovascularization
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Cell Invasion
- Inflammation
- Nephroblastoma
Pathways
- Angiogenesis
- Cell Proliferation
- Cell Adhesion
- Cell Migration
- Cell Growth
- Pathogenesis
- Wound Healing
- Localization
- Secretion
- Cell Cycle
- Chemotaxis
- Cell Death
- Cell Differentiation
PTMs
- Phosphorylation
- Reduction
- Cleavage
- Acetylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCN1
bosterbio.com/bosterbio-gene-info-cards/CCN1
References
PMID: 9135077 by Jay P., et al. The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.
PMID: 9536281 by Martinerie C., et al. Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.
1 Publications of Boster CCN family member 1 Antibodies & ELISA Kits
- PubMed ID: 10.1042/CS20180474, Novel treatment avenues for uterine leiomyoma: a new implication for endothelin?
*More publications can be found for each product on its corresponding product page