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- Table of Contents
Facts about C-C motif chemokine 16.
Recombinant SCYA16 reveals chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Human | |
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Gene Name: | CCL16 |
Uniprot: | O15467 |
Entrez: | 6360 |
Belongs to: |
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intercrine beta (chemokine CC) family |
C-C motif chemokine 16; CCL16; chemokine (C-C motif) ligand 16; Chemokine CC-4; Chemokine LEC; CKb12; HCC4; HCC-4; HCC-4Liver-expressed chemokine; LCC-1Lymphocyte and monocyte chemoattractant; LEC; liver CC chemokine-1; LMC; LMCSmall-inducible cytokine A16; monotactin-1; Mtn-1; NCC-4; NCC4IL-10-inducible chemokine; NCC-4ILINCK; new CC chemokine 4; SCYA16MGC117051; SCYL4; small inducible cytokine subfamily A (Cys-Cys), member 16
Mass (kDA):
13.6 kDA
Human | |
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Location: | 17q12 |
Sequence: | 17; NC_000017.11 (35976493..35983620, complement) |
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Secreted.
PMID: 9596672 by Hedrick J.A., et al. Characterization of a novel CC chemokine, HCC-4, whose expression is increased by interleukin-10.
PMID: 9545580 by Shoudai K., et al. Isolation of cDNA encoding a novel human CC chemokine NCC-4/LEC.