CCDC8 Antibodies

AND CCDC8 ELISA kits, CCDC8 Proteins

Many biological assays use antibodies to detect CCDC8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCDC8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCDC8 antibodies...

We validate the specificity of these antibodies to CCDC8 by testing them on tissues known to express CCDC8 positively and negatively. Browse below to find the CCDC8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCDC8 Infographic by Boster Bio

All CCDC8 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CCDC8 Antibody

Human

ELISA, WB

$380
Cat # A08066
100ul

CCDC8 (NM_032040) Human Over-expression Lysate

Human

$628
Cat # LS083987
100 µg

CCDC8 Overview

Facts about Coiled-coil domain-containing protein 8.

CCDC8 3D structure. Source: alphafold

Coiled-coil domain-containing protein 8 (CCDC8)

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is uncertain how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696).

Required for localization of CUL7 to the centrosome (PubMed:24793695). .

Gene Information

Human
Gene Name:	CCDC8
Uniprot:	Q9H0W5
Entrez:	83987

Family

Belongs to:

No superfamily

Alternative Names

coiled-coil domain containing 8; coiled-coil domain-containing protein 8; DKFZp564K0322

Molecular Weight

Mass (kDA):
59.374 kDA

Genomic Context


Human

Location:	19q13.32
Sequence:	19; NC_000019.10 (46410329..46413564, complement)

Tissue Specificity

Widely expressed with low levels in spleen, skeletal muscle, small intestine, kidney and liver.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Diseases

3m Syndrome
Dwarfism
Muscle Hypotonia
Growth Disorders
Neoplasms
Russell-silver Syndrome
Primary Neoplasm
Neoplasm By Morphology
Glioma
Oligodendroglioma

Kidney Neoplasm
Carcinoma
Malignant Neoplasms
Renal Cell Carcinoma

Pathways

Methylation

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCDC8

References

PMID: 21737058 by Hanson D., et al. Exome sequencing identifies CCDC8 mutations in 3-M syndrome, Suggesting that CCDC8 Contributes in a Pathway with CUL7 and OBSL1 to Control Human Growth.

PMID: 23018678 by Hanson D., et al. Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling.