CCDC66 Antibodies

AND CCDC66 ELISA kits, CCDC66 Proteins

Many biological assays use antibodies to detect CCDC66, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CCDC66 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CCDC66 antibodies...

We validate the specificity of these antibodies to CCDC66 by testing them on tissues known to express CCDC66 positively and negatively. Browse below to find the CCDC66 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CCDC66 Infographic by Boster Bio

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CCDC66 Overview

Facts about Coiled-coil domain-containing protein 66.

CCDC66 3D structure. Source: alphafold

Coiled-coil domain-containing protein 66 (CCDC66)

Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins such as BBS4 into the cilium, but also through the organization of the centriolar satellites (PubMed:28235840).

Plays a role in retina morphogenesis and/or homeostasis (By similarity). .

Gene Information

Human
Gene Name:	CCDC66
Uniprot:	A2RUB6
Entrez:	285331

Family

Belongs to:

No superfamily

Alternative Names

coiled-coil domain containing 66; coiled-coil domain-containing protein 66; DKFZp686C0433

Molecular Weight

Mass (kDA):
109.411 kDA

Genomic Context


Human

Location:	3p14.3
Sequence:	3; NC_000003.12 (56557125..56621837)

Tissue Specificity

Widely expressed (at protein level) (PubMed:28235840). Expressed in retina, mainly in photoreceptors but also in outer plexiform and ganglion cell layers (at protein level) (PubMed:19777273).

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273).

Diseases

Retinal Degeneration
Atrophy
Atrophic Retina
Generalized Progressive Retinal Atrophy
Dysplasia
Night Blindness
Retinitis Pigmentosa

Retinal Diseases
Blind Vision

Pathways

Pathogenesis
Rna Splicing

PTMs

Disulfide bond

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CCDC66

References

PMID: 19777273 by Dekomien G., et al. Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene.

PMID: 28235840 by Conkar D., et al. The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking.