CBR4 Antibodies

AND CBR4 ELISA kits, CBR4 Proteins

Many biological assays use antibodies to detect CBR4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBR4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBR4 antibodies...

We validate the specificity of these antibodies to CBR4 by testing them on tissues known to express CBR4 positively and negatively. Browse below to find the CBR4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CBR4 Infographic by Boster Bio

All CBR4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-CBR4 Antibody

Human, Rat

$405
Cat # A07359
100ul

Human CBR4 Recombinant Protein

SDS-PAGE

$265
Cat # PROTQ8N4T8
Starting from 10ug

Anti-CBR4 Mouse Monoclonal Antibody [Clone ID: OTI3C10]

Human, Mouse, Rat

IHC

$523
Cat # M07359
100 µl

CBR4 (NM_032783) Human Over-expression Lysate

Human

$628
Cat # LS084869
100 µg

CBR4 Overview

Facts about Carbonyl reductase family member 4.

CBR4 3D structure. Source: alphafold

Carbonyl reductase family member 4 (CBR4)

The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).

The homotetramer has NADPH-dependent quinone reductase activity (PubMed:19000905). The two homotetramer and the heterotetramer have broad substrate specificity and can reduce 9,10- phenanthrenequinone, 1,4-benzoquinone and several other o-quinones and p-quinones (in vitro) (PubMed:19000905, PubMed:19571038, PubMed:25203508).

Gene Information

Human
Gene Name:	CBR4
Uniprot:	Q8N4T8
Entrez:	84869

Family

Belongs to:

short-chain dehydrogenases/reductases (SDR) family

Alternative Names

3-oxoacyl-[acyl-carrier-protein] reductase; carbonic reductase 4; carbonyl reductase 4; carbonyl reductase family member 4; EC 1.1.1; EC 1.1.1.-; EC 1.1.1.100; FLJ14431; Quinone reductase CBR4; SDR45C1; short chain dehydrogenase/reductase family 45C, member 1

Molecular Weight

Mass (kDA):
25.301 kDA

Genomic Context


Human

Location:	4q32.3
Sequence:	4; NC_000004.12 (168894484..169010284, complement)

Tissue Specificity

Detected in liver and kidney (at protein level).

Subcellular Localizations

Mitochondrion matrix.

Diseases

Malignant Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms

Pathways

Methylation
Drug Resistance
Induction Of Apoptosis
Dna Methylation
Demethylation

PTMs

Demethylation

Methylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBR4

References

PMID: 19000905 by Endo S., et al. Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase.

PMID: 19571038 by Chen Z., et al. 17beta-Hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS.