CBLL1 Antibodies

AND CBLL1 ELISA kits, CBLL1 Proteins

Many biological assays use antibodies to detect CBLL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CBLL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CBLL1 antibodies...

We validate the specificity of these antibodies to CBLL1 by testing them on tissues known to express CBLL1 positively and negatively. Browse below to find the CBLL1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CBLL1 Infographic by Boster Bio

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CBLL1 (NM_024814) Human Over-expression Lysate

Human

$960
Cat # LS079872
100 µg

CBLL1 Overview

Facts about E3 ubiquitin-protein ligase Hakai.

CBLL1 3D structure. Source: alphafold

E3 ubiquitin-protein ligase Hakai (CBLL1)

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity).

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification which plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755).

Gene Information

Human
Gene Name:	CBLL1
Uniprot:	Q75N03
Entrez:	79872

Family

Belongs to:

Hakai family

Alternative Names

Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; c-Cbl-like protein 1; E3 ubiquitin-protein ligase Hakai; EC 6.3.2; EC 6.3.2.-; E-cadherin binding protein E7; HAKAIRNF188FLJ23109; MGC163401; MGC163403; RING finger protein 188

Molecular Weight

Mass (kDA):
54.519 kDA

Genomic Context


Human

Location:	7q22.3
Sequence:	7; NC_000007.14 (107743697..107764997)

Subcellular Localizations

Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Tumor Progression
Carcinoma
Mammary Neoplasms
Cell Transformation, Neoplastic
Neoplasm Invasiveness
Carcinogenesis
Cell Invasion
Primary Neoplasm

Tissue Adhesions
Dengue Fever
Virus Diseases
Yellow Fever
West Nile Viral Infection
Tick-borne Encephalitis
Metastatic Malignant Neoplasm To The Liver

Interacting Proteins

RBM10

Pathways

Endocytosis
Cell Proliferation
Translation
Rna Interference
Methylation
Secretory Pathway
Cell Migration
Dna Methylation

Cell-matrix Adhesion
Viral Replication
Oncogenesis

PTMs

Ubiquitination

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CBLL1

References

PMID: 24100041 by Horiuchi K., et al. Identification of Wilms' tumor 1-associating protein complex and its role in alternative splicing and the cell cycle.

PMID: 29507755 by Yue Y., et al. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.