Caspase-10 Antibodies

Caspase-10 (CASP10)

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner.

May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9.

Gene Information

Human
Gene Name:	CASP10
Uniprot:	Q92851
Entrez:	843

Family

Belongs to:
peptidase C14A family

Alternative Names

Apoptotic protease Mch-4; CASP10; CASP-10; caspase 10, apoptosis-related cysteine peptidase; caspase 10, apoptosis-related cysteine protease; Caspase10; Caspase-10; EC 3.4.22.63; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-converting enzyme 2; FLICE2; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; Mch4; MCH4ALPS2

Molecular Weight

Mass (kDA):
58.951 kDA

Genomic Context

Human
Location:	2q33.1
Sequence:	2; NC_000002.12 (201182885..201229406)

Tissue Specificity

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Diseases

• Malignant Neoplasms
• Neoplasms
• Autoimmune Lymphoproliferative Syndrome
• Autoimmune Reaction
• Mammary Neoplasms
• Carcinoma
• Autoimmune Diseases
• Lymphoproliferative Disorders
• Leukemia
• Malignant Neoplasm Of Breast
• Malignant Neoplasm Of Lung
• Neuroblastoma
• Lung Neoplasms

• Lymphoma
• Adenocarcinoma
• Malignant Paraganglionic Neoplasm
• Non-small Cell Lung Carcinoma
• Lymphoma, Non-hodgkin
• Malignant Neoplasm Of Stomach
• Autoimmunity

Interacting Proteins

• CASP8
• CFLAR
• RIOK3
• RIPK1
• XIAP

Pathways

• Cell Death
• Pathogenesis
• Programmed Cell Death
• Methylation
• Cell Proliferation
• Induction Of Apoptosis
• Cell Cycle
• Localization
• Cell Growth
• Mitochondrial Depolarization
• Transport
• Gene Silencing
• Proteolysis

• Sensitization
• Lymphocyte Homeostasis
• Viral Replication
• Apoptotic Process
• Autophagy
• Cell Adhesion
• Myelination

PTMs

• Cleavage
• Phosphorylation
• Methylation

• Demethylation
• Biotinylation
• Acetylation

• Dephosphorylation

Research Areas

• Apoptosis
• Breast Cancer
• Cancer
• Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP10

Boster Bio - The Best Uses Of The CASP10 Marker

Boster Bio is an antibody manufacturer and is committed to providing the highest quality antibodies to researchers. Boster Bio validates all its antibodies on WB and IHC. Boster produces antibodies with high-affinity. They also ensure high affinity and specificity. The company awards product credits to scientists who are the first ones to review their products. Continue reading to learn about Boster.

Boster Bio offers high-affinity primary antibodies

There are many ways that you can measure and analyze CASP10's presence in samples. The techniques used by biomedical researchers vary greatly and can be complicated. Boster Bio provides high affinity primary antibodies against this mark to simplify the process. These antibodies are either monoclonal, or polyclonal. The antibodies are well-cited and have been used in research since more than 25 years.

Boster validates all antibodies against WB, IHC and ICC. Immunofluorescence, Immunofluorescence, and Immunofluorescence

To ensure consistency, Boster Bio validates all of its antibodies on WB, IHC, IC, and immunofluorescence methods. These assays include WB (IHC, ICC, and immunefluorescence), which are the most widely used in pathology. All antibodies were tested in a laboratory that validates histology. These antibodies are tested and validated to ensure their quality.

Boster has a wide selection of primary antibodies. They are all validated for WB. Their antibodies are reliable. They have been extensively validated using WB, IHC ICC and immunofluorescence. Boster's antibodies are also available in rabbit polyclonal, mouse polyclonal, and monoclonal forms. Customers can get a free secondary antibodies with every Boster product.

Boster Bio has created a step-by–step guide for the IHC process. The IHC guide gives detailed instructions on how to complete each step, including sample preparation as well as antigen retrieval. It also offers tips for optimal sample preparation. This includes methods for different types and preserved tissues. A high-quality staining process requires that the tissue be preserved in a healthy manner.

Each antibody is rigorously tested in WB, IHC, ICC, and other quality control methods. Boster bio uses trade secrets to validate all antibodies, including a PicoKine proprietary ELISA platform. This proprietary ELISA platform was created to deliver sensitive ELISA kits with high sensitivity.

Validation begins at the primary antibodies. The primary antibody is created by immunizing a host with another species of antibody. This is most often a rabbit. The second antibody is then produced in a different species. The two antibodies will be highly specific for the same antibody. These primary antibodies exhibit high specificity and an affinity of approximately 91% or more.

Another way to check for quality is to use Isotype Controls. Background levels may be higher when comparing the isotype control with the target antibody. For untested samples, it is important to always use isotype control. They can be extremely helpful in interpreting results from ICC and WB immunofluorescence tests. They are a good indicator of background.

History of Steven Boster

You are interested in finding out more about Steven Boster's past? Start by looking at his public records. Public records include Steve’s current address, his previous addresses, cell phone numbers and email addresses, aswell as any known relatives. These records can be used by you to narrow down your search to Steve Boster’s state or age. You can also look for people with the same name as Steve. Read on to learn more about Steve's family.

After a long struggle with COVID-19 Steve Boster, he died in Madison WI on June 6, 2022. He was born on July 6, 1926, in Joliet, IL. He was the son James Meier Boster and Evelyn Meier Boster. He was a member of Concordia Hall in Staunton, VA. His surviving family members include his two daughters, Crystal Boster and Natosha Peck, 6 grandchildren, and 4 brothers, Jack Boster. His sister, Lisa Milton, and many nieces and nephews.