CARD8 Antibodies

AND CARD8 ELISA kits, CARD8 Proteins

Many biological assays use antibodies to detect CARD8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CARD8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CARD8 antibodies...

We validate the specificity of these antibodies to CARD8 by testing them on tissues known to express CARD8 positively and negatively. Browse below to find the CARD8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CARD8 Infographic by Boster Bio

All CARD8 Products

Product

Figures

Specificity

Applications

Price

Anti-CARD8 (Tucan) Antibody

3 Q&As

Human

IP, IHC, WB

$328
Cat # A03404
50 µl

Anti-CARD8 Antibody

Human

ELISA, IF, ICC, WB

$449
Cat # A03404-1
0.1 mg

CARD8 Overview

Facts about Caspase recruitment domain-containing protein 8.

CARD8 3D structure. Source: alphafold

Caspase recruitment domain-containing protein 8 (CARD8)

Inhibits NF-kappa-B activation.
May participate in a regulatory mechanism which coordinates cellular responses controlled by NF-kappa-B transcription element.

Might be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases. .

Gene Information

Human
Gene Name:	CARD8
Uniprot:	Q9Y2G2
Entrez:	22900

Family

Belongs to:

No superfamily

Alternative Names

Apoptotic protein NDPP1; CARD inhibitor of NF-kappaB-activating ligands; CARDINALFLJ18121; CARD-inhibitor of NF-kappa-B-activating ligand; caspase recruitment domain family, member 8; caspase recruitment domain-containing protein 8; DACAR; DAKAR; KIAA0955DKFZp779L0366; NDPP; NDPP1MGC57162; TUCANFLJ18119; Tumor up-regulated CARD-containing antagonist of CASP9; tumor up-regulated CARD-containing antagonist of caspase nine

Molecular Weight

Mass (kDA):
48.933 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (48203148..48256264, complement)

Tissue Specificity

High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Inflammation
Crohn Disease
Malignant Neoplasms
Arthritis
Inflammatory Bowel Diseases
Neoplasms
Intestinal Diseases
Rheumatoid Arthritis
Ulcer
Inflammatory Response
Innate Immune Response
Colitis
Ulcerative Colitis

Autoimmune Diseases
Malignant Neoplasm Of Lung
Inflammatory Disorder
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Malignant Tumor Of Colon
Dysequilibrium Syndrome

Pathways

Cell Death
Pathogenesis
Immune Response
Inflammatory Response
Cell Cycle
Innate Immune Response
Cell Proliferation
Induction Of Apoptosis
Localization
Cytokine Production
Rna Interference
Secretion
Protein Phosphorylation

Programmed Cell Death
Adaptive Immune Response
Interleukin-1 Beta Secretion
Flight
Translation
Interleukin-1 Production
Oncogenesis

PTMs

Phosphorylation

Cleavage

Research Areas

Apoptosis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CARD8

References

PMID: 11821383 by Razmara M., et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

PMID: 11956601 by Zhang H., et al. NDPP1 is a novel CARD domain containing protein which can inhibit apoptosis and suppress NF-kappaB activation.