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CAPN2 Antibodies
AND CAPN2 ELISA kits, CAPN2 Proteins
Many biological assays use antibodies to detect CAPN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CAPN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CAPN2 antibodies...
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CAPN2 Infographic by Boster Bio
All CAPN2 Products
Product
Figures
Specificity
Applications
Price
Anti-Calpain 2/CAPN2 Antibody Picoband®
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03492
100 μg/vial
Cat # A03492
100 μg/vial
Anti-Calpain 2 CAPN2 Antibody Picoband® (monoclonal, 8I6)
1 Citations 3 Q&As
Human, Monkey, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03492
100 μg/vial
Cat # M03492
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IHC, ICC, WB
$405
Cat # A03492-1
100ul
Cat # A03492-1
100ul
Human, Monkey, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M03492-1
100 µl
Cat # M03492-1
100 µl
CAPN2 Overview
Facts about Calpain-2 catalytic subunit.
Calpain-2 catalytic subunit (CAPN2)
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at'Arg-226' (PubMed:17650508).
Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | CAPN2 |
| Uniprot: | P17655 |
| Entrez: | 824 |
Family
| Belongs to: |
|---|
| peptidase C2 family |
Alternative Names
Calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; calpain, large polypeptide L2; calpain-2 catalytic subunit; Calpain-2 large subunit; CANP 2; CANPL2CANP2; CANPml; EC 3.4.22; EC 3.4.22.53; FLJ39928; M-calpain; mCANP; millimolar-calpain
Molecular Weight
Mass (kDA):
79.995 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q41 |
| Sequence: | 1; NC_000001.11 (223701593..223776018) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca(2+) binding.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Protrusion
- Cell Invasion
- Neoplasm Metastasis
- Glioma
- Liver Carcinoma
- Malignant Paraganglionic Neoplasm
- Diabetes Mellitus
Interacting Proteins
- CAPNS1
- ZDHHC17
Pathways
- Cell Migration
- Proteolysis
- Pathogenesis
- Secretion
- Cell Adhesion
- Cell Cycle
- Localization
- Cell Division
- Wound Healing
- Mitosis
- Cell Death
- Cell Growth
- Autophagy
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAPN2
bosterbio.com/bosterbio-gene-info-cards/CAPN2
References
PMID: 2852952 by Imajoh S., et al. Molecular cloning of the cDNA for the large subunit of the high-Ca2+- requiring form of human Ca2+-activated neutral protease.
PMID: 10944468 by Ye Z., et al. cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.
2 Publications of Boster CAPN2 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fcell.2021.684857, Tunicamycin Induces Hepatic Stellate Cell Apoptosis Through Calpain-2/Ca2 +-Depe...
- PubMed ID: 25415668, Chen Hx, Tang Sp, Gao Ft, Xu Jl, Jiang Xp, Cao J, Fu Gb, Sun K, Liu Sz, Shi W. M...
*More publications can be found for each product on its corresponding product page