Calpain-3 Antibodies

AND CAPN3 ELISA kits, Calpain-3 Proteins

Many biological assays use antibodies to detect Calpain-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Calpain-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Calpain-3 antibodies...

We validate the specificity of these antibodies to Calpain-3 by testing them on tissues known to express CAPN3 positively and negatively. Browse below to find the CAPN3 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CAPN3 Infographic by Boster Bio

All CAPN3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Calpain-3 CAPN3 Antibody

Mouse, Rat

IF, ICC, WB

$405
Cat # A02170
100ul

Anti-CAN3 CAPN3 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02170-1
100ul

Calpain 3 (CAPN3) (NM_173089) Human Over-expression Lysate

Human

$628
Cat # LS000825
100 µg

CAPN3 Overview

Facts about Calpain-3.

CAPN3 3D structure. Source: alphafold

Calpain-3 (CAPN3)

Calcium-regulated non-lysosomal thiol-protease. .

Gene Information

Human
Gene Name:	CAPN3
Uniprot:	P20807
Entrez:	825

Family

Belongs to:

peptidase C2 family

Alternative Names

calpain 3, (p94); Calpain L3; Calpain p94; calpain, large polypeptide L3; calpain-3; CANP 3; CANP3MGC4403; CANPL3; EC 3.4.22; EC 3.4.22.54; LGMD2; LGMD2A; MGC10767; MGC11121; MGC14344; muscle-specific calcium-activated neutral protease 3 large subunit; Muscle-specific calcium-activated neutral protease 3; NCL1; nCL-1large [catalytic] subunit; New calpain 1

Molecular Weight

Mass (kDA):
94.254 kDA

Genomic Context


Human

Location:	15q15.1
Sequence:	15; NC_000015.10 (42359500..42412317)

Tissue Specificity

Isoform I is skeletal muscle specific.

Subcellular Localizations

Cytoplasm.

Diseases

Muscular Dystrophy
Dystrophy
Muscular Dystrophies, Limb-girdle
Leyden-moebius Muscular Dystrophy
Myopathy
Atrophy
Weakness
Muscular Atrophy
Myositis
Muscle Weakness
Neuromuscular Diseases
Hereditary Diseases

Muscle Contracture
Muscular Dystrophy, Duchenne
Protein Deficiency
Sore To Touch
Diabetes Mellitus, Non-insulin-dependent
Sarcoglycanopathies
Muscular Dystrophy, Tibial

Interacting Proteins

OSGIN1
TFCP2
TTN
WDYHV1

Pathways

Autolysis
Localization
Proteolysis
Pathogenesis
Regeneration
Muscle Atrophy
Translation
Cell Cycle
Myoblast Fusion
Aging
Muscle Contraction
Reverse Transcription
Mrna Processing

Cell Proliferation
Dna Methylation
Glycosylation
Methylation
Cell Death
Cell Adhesion
Transport

PTMs

Cleavage
Oxidation
Ubiquitination

Sumoylation
Reduction
Glycosylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAPN3

References

PMID: 7720071 by Richard I., et al. Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A.

PMID: 2555341 by Sorimachi H., et al. Molecular cloning of a novel mammalian calcium-dependent protease distinct from both m- and mu-types. Specific expression of the mRNA in skeletal muscle.