Cant1 Antibodies

Soluble calcium-activated nucleotidase 1 (Cant1)

Calcium-dependent nucleotidase with a Taste for UDP.

The order of activity with various substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP.

Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP.

Gene Information

Mouse
Gene Name:	Cant1
Uniprot:	Q8VCF1
Entrez:	76025

Family

Belongs to:
apyrase family

Alternative Names

Apyrase homolog; calcium activated nucleotidase 1; CANT1; DBQD; EC 3.6.1.6; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107; SCAN1; SCAN-1Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase; SHAPY; SHAPYmicromelic dwarfism with vertebral and metaphyseal abnormalities and advancedcarpotarsal ossification; soluble Ca-activated nucleotidase, isozyme 1; soluble calcium-activated nucleotidase 1; soluble calcium-activated nucleotidase SCAN-1

Molecular Weight

Mass (kDA):
45.653 kDA

Genomic Context

Mouse
Location:	11 E2|11 83.15 cM
Sequence:	11;

Diseases

• Dysplasia
• Desbuquois Syndrome
• Dwarfism
• Malignant Neoplasms
• Craniofacial Abnormalities
• Congenital Hand Deformities
• Heterotopic Ossification
• Malignant Neoplasm Of Prostate
• Polydactyly
• Prostatic Neoplasms
• Neoplasms
• Bone Diseases, Developmental

• Skeletal Dysplasia
• Dislocations
• Hydrops Fetalis
• Neoplasm Metastasis
• Mutation Abnormality
• Joint Laxity
• Intraepithelial Neoplasia

Pathways

• Ossification
• Endochondral Ossification
• Cell Proliferation
• Bone Maturation
• Protein Maturation
• Protein Secretion
• Cell Cycle Arrest
• Translation
• Cell Cycle
• Protein Folding

• Wound Healing
• Catabolic Process
• Rna Interference
• Secretion

PTMs

• Glycoprotein

Research Areas

• Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Cant1

Boster Bio: Best Uses Of The CANT1 Marker

You have come to the right spot if you are looking for more information about Boster Bio's Anti-CANT1 Marker. This article will discuss the anti-CANT1 marker and its clinical uses. We'll also look at its availability and cost. The BosterBio: Best uses of the CANT1 Marker anti-body has been tested in Western Blot, ELISA, and PCR. It is compatible with human and mouse cells.

Boster Bio Anti-CANT1 Marker

Boster Bio Anti–CANT1 Markers uses primary antibodies from Rat, Mouse, and Human. They are backed up by solid research and have been tested using ELISA, WB and ELISA. These markers are packaged with a blocking peptide that blocks MR1 and Trehalose. This kit can be stored at 4@C or -20degC for six months.

The Boster Bio Anti-CANT1 Markers have been proven to be highly sensitive and specific in a wide range of lab applications. Their innovative approach has helped them become one of the largest antibody catalog companies in China by the end of the 90s. PicoKine (tm) ELISA platform is one of their trade secrets. It allows for high-sensitivity ELISA tests.

Clinical applications

Nearly all human beings have the CANT1 gene. It can also be found in mouse tissues. CANT1 was found in 92% of patients suffering from LA. This mutation was a result of a common haplotype (500 kb) in two patients with LA. The UCSC Genome Browser revealed the genetic code for CANT1 in the human genome. CANT1 isn't used in the clinic to diagnose patients, but it is useful in research.

The role of CANT1 in lung cancer is still unknown. CANT1 functions in a calcium-dependent nucleotidase. It prefers UDP rather than GTP. CANT1 is often associated with cancer cells due to its alternative splicing transcript variants. This gene has an abnormal alternative splicing profile that promotes cell proliferation, migration, as well as apoptosis resistance. Hence, the CANT1 gene may serve as a biomarker in LA.

In vitro, the CANT1 gene performs many biological functions. Mutations in this gene can cause partial or complete loss in enzyme function. CANT1 mutations only affect the skeleton. As such, it is difficult to obtain skeletal tissue biopsies for DBQD1 sufferers. It is therefore important to obtain a reliable skeletal biopsy from such patients to detect any abnormalities.

Although the clinical consequences of the CANT1 genetic mutation are unknown, it seems that the gene appears to be widely expressed in many tissues such as bone and cartilage. This may be due to the higher sugar levels required for GAG synthesis in these tissues. Alternated GAG synthesis may also have deeper physiological effects in other tissues. These changes may be due to different strategies for Golgi glucosylation and nucleotidases.

Accessibility

Researchers and clinicians can both benefit from the availability of the CANT1 gene in boster bio products. The company produces high-affinity, polyclonal antibodies that can be used in immunohistochemistry or Western blotting. The antibodies have been tested against 250 cell types and tissues. Research community trusts Boster bio products. Sanbio, the distributor in Belgium, offers technical support to the company.

CANT1 is a calcium-activated nuclear nucleotidase which prefers uridine dimphosphate to ATP. Although the protein has potential clinical use in the treatment and prevention of lung cancer, commercially available tests do not yet have it. Bioinformatics analysis has suggested that CANT1 may have a biological role in this condition.

CANT1 alters the metabolism glycine, purine, and threonine. It also affects glycosphingolipid biosynthesis. It has been linked to tumorigenesis via the MAPK/NF-kB signaling pathways. There is only limited literature on the relationship between CANT1 and LA, but it may have some prognostic value in patients.

Cost

When selecting a diagnostic test, you should consider the cost of CANT1 markers. The CANT1 gene can be found within the human genome. The cost of human CANT1 cells and the number needed for testing determines the cost of the CANT1 mark. The article Cost of a CANT1 mark provides more information. Here is a summary of the costs and benefits associated the CANT1 gene-marker.

After ultracentrifugation separation, the CANT1 protein is found in its soluble state. It is unknown whether CANT1 plays a role in signaling, protein fold, or protein glycosylation. Although CANT1's function is saturable it appears to favor glycosylation. This study is a useful tool for researchers. But there is a high cost associated with the CANT1 marker.

CANT1 gene is expressed in prostate tumor cells but not in normal tissues. This makes it a useful ancillary marker for cancer diagnosis. However, it is unable to distinguish between invasive and PIN carcinomas. This marker requires a lot more research and is expensive. It is worth the cost for the additional insight it provides into a patient with cancer.

CANT1 acts as a nucleotide hydroxylase and is involved in intracellular glycosylation reactions. It was found in the supernatant transfected COS-1 cells. This indicates that it is secreted to the cytoplasm. Finally, the soluble secreted form of CANT1 suggests that it may modulate cellular responses to extracellular UDP through pyrimidinergic receptors.